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《Chinese Traditional and Herbal Drugs》 2006-02
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Effect of 2-hydroxypropyl-β-cyclodextrin on solubility and stability of garlic oil

SONG Hong-tao~1,GUO Tao~2,ZHANG Yue-xin~2,HAN Wei~3,WANG Zhi-yuan~3,HE Jin~2,HE Zhong-gui~3(1.Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China;2.Department of Pharmacy,The General Hospital of Shenyang Military Region,Shenyang 110016,China;3.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)  
Objective To investigate the effects of 2-hydroxypropyl-β-cyclodextrin(HP-β-CD) on the solubility and stability of garlic oil.Methods The solubility of allicin of garlic oil in various concentration of HP-β-CD water solution was determined by GC.The content of allicin was used as an index to compare the stability of garlic oil HP-β-CD water solution with garlic oil Tween-80 water solution under the conditions of 40 ℃,60 ℃,and light(4 500 lx).The effects of pH value,antioxidants,nitrogen gas,and sterilizing on the stability of allicin of garlic oil in 5% HP-β-CD water solution were investigated.Results The solubility of allicin of garlic oil in water could be improved remarkably by HP-β-CD and increased linearly along with the increasing of HP-β-CD concentration.The allicin of garlic oil was more stable in HP-β-CD water solution than in Tween-80 water solution while in pH value 5.0 and with nitrogen gas.The stablity of allicin of garlic oil was decreased under the conditions of heating,lighting,or adding antioxidants.Conclusion HP-β-CD could evidently increase the solubility of allicin of garlic oil in water and improve its stability.
【Fund】: 辽宁省科学技术基金资助项目(20022059)
【CateGory Index】: R284.1
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【References】
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1 ZHANG Qian(School of Pharmacy,Fujian Medical University,Fuzhou 350004,China) ZHANG Jing,ZHOU Xin,SONG Hong-tao(Dept.of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China);Effect of Hydroxypropyl-β-Cyclodextrin on Solubility of Tacrolimus[J];China Pharmacy;2010-25
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