Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Traditional and Herbal Drugs》 2006-02
Add to Favorite Get Latest Update

Protection and mechanism of notoginsenoside-Rg_1 on focal cerebral ischemia-reperfusion rats

WU Lan-ou,ZHAN He-qin,YAN Jun-ling,CAI Wen-feng,WU Jinping,YANG Ke-hong(Department of Pharmacology,Kunming Medical College,Kunming 650031,China)  
Objective To explore the effects of notoginsenoside-Rg_1 on brain-derived neurotrophic factor(BDNF) protein in cerebrum cortex of MCAO/R injury,as well as to investigate whether notoginsenoside-Rg_1 can up-regulate the protein content of BDNF of the positive neurons or the amount of the po-sitive neurons.Methods Adult male SD rats(60) were randomly divided into model group,notoginsenoside-Rg_1 high,middle,and low dose(200,100,50 mg/kg) groups,and the positive control(Nimodipine,1 mg/kg) group.All drugs were given once a day by ip till the mouse was killed.The focal cerebral(ischemia-)reperfusion model was made with thread-occluded method.Their frozen brain tissue were sliced(into) section of 12 μm thickness.The four rats were randomly taken from each groups to be treated as specimens after surgical handle in 1,3,and 7 d.The slices were according to the immunohistochemical ABC techniques.The protein content of BDNF of the positive neurons and the amount of the positive neurons in cerebrum cortex of rat were observed and counted by HPIAS—1000 analytic system,and the nervous deficit symptoms after the cerebral ischemia were observed.Results Comparing with the model group,all notoginsenoside-Rg_1 treated groups obviously improved some nervous deficit symptoms of cerebral ischemia-reperfusion rats,and increased the protein content of BDNF and the amount of the positive neurons in the cerebrum cortex of model rats(P0.05).In different groups,the effect of notoginsenoside-Rg_1 was superior to that of Nimodipine or equated to it.Conclusion Notoginsenoside-Rg_1 could up-regulate the expression of BDNF and increase the amount of positive neurons in cerebrum cortex.It treated cerebral ischemia by the protection of BDNF on neurons injury in the focal cerebral ischemia-reperfusion,which can be one of the mechanism of the protection of notoginsenoside-Rg_1 on focal cerebral(ischemia) reperfusion injury.
【Fund】: 云南省自然科学基金项目(2002C0051m)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 9 Hits
1 WEI Wei, XIE Sheng-rong, FU Ji-hua, LIU Wen, QI Jian-ping, PING Qi-neng Department of Physiology, China Pharmaceutical University, Nangjing 210009, China;Anti-inflammatory Effects of Components in Shuxiong Tablet and Its Possible Formulary Rationality[J];中草药(英文版);2010-04
2 YANG Zhi-hui,YANG Rui,LU Yang(Pharmacy Department,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China);Neuroprotective effects of NsTyr against OGD-induced apoptosis on cortical neurons[J];Drugs & Clinic;2010-05
3 HE Qiong~1,TAN Chu-bing~2,ZHAO Qin~1 1.Department of Neurology,Staff Hospital of Xiangtan Steel and Iron Group Co.,Ltd.,Xiangtan 411101,China 2.Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193, China;Clinical observation of Xuesaitong Injection combined with conventional treatment on patients with cerebral infarction[J];Drugs & Clinic;2011-03
4 ZHANG Ke 1) , LI Hua 2) ,WANG Jun 3) 1)Department of Internal Medicine,the Second Clinic of Henan Provincial Administration, Zhengzhou 450003 2)Department of Geriatrics,the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 3)Pharmacology Research Institute of Chinese Medicine Academy in Henan, Zhengzhou 450004;Protective effect of panax notoginsenosides on renal ischemia reperfusion injury in rats[J];Journal of Zhengzhou University(Medical Sciences);2006-06
5 Chen Yan, Jinqiang Zhu, Xiaoxu Jia, Chao Wang, Shaoxia Wang, Liyuan Kang Key Laboratory for Prescription of National Educational Ministry of China, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons[J];中国神经再生研究(英文版);2012-36
6 SHI Sheng-ming1,2,YUAN Yong-bin1,CHEN Chang-qing1,ZHAO Yu-qing2 1.Center of Medicinal Information,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China 2.College of Shenyang Pharmaceutical University,Shenyang 110016,China;Application of HPLC in modern pharmaceutical study on root of Panax notoginseng and its preparation[J];Drug Evaluation Research;2010-06
7 WU Chang-qing1,WANG Chun-yan1,SHAO Xu2,DONG Liu-yi1 1.Key Laboratory of Anti-inflammatory and Immunopharmacology,Ministry of Education;Key Laboratory of Chinese Medicine Research and Development,State Administration of Traditional Chinese Medicine;Department of Pharmacology,Anhui Medical University,Hefei 230032,China 2.Hefei Qi-xing Pharmaceutical Medicine and Technology Co.,Ltd.,Hefei 230088,Chin;Protection and mechanism of effective fraction from Buyang Huanwu Decoction on focal cerebral ischemia-reperfusion injury in rats[J];Chinese Traditional and Herbal Drugs;2011-01
8 MENG Lanqing, WEI Yesheng, WEI Shige, et al. Author′s address Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, 533000;Effects of panax notoginseng saponins on serum TNF-α and IL-6 levels in patients with acute cerebral infarction[J];Chinese Journal of Rehabilitation Medicine;2008-03
9 TANG Jing-shu1,PEI Qing-hua2(1.Peking University Health Science Center,Beijing 100191,China; 2.The 3rd Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China);Neuroprotective Role of Panax Notoginseng Saponins on Cerebral Ischemia-reperfusion Injury in Rats[J];Chinese Journal of Experimental Traditional Medical Formulae;2011-15
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 TANG Xu dong, JIANG Jian qing, LIU Bao yu,ZHOU Kai,DING Sheng,YU Yong kang (Department of Thoracic and Cardiovascular Surgery,the General Hospital of Chengdu Military Region,PLA,Sichuan Chengdu 610083,China);Molecular Mechanism of Protective Effect of Total Saponins of Panax Notoginseny against Myocardial Ischemia Reperfusion Injury[J];Journal of Anhui Traditional Chinese Medical College;2003-01
2 ZHANG Xiao bing, PENG Dai yin, ZHU Man fang,ZHOU Ya Qiu, LIU Qing yun (Department of Pharmacy, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Protective Effect of Breviscapine Dropping Pill Against Focal Cerebral Ischemia Reperfusion Injury in Rats[J];Journal of Anhui Traditional Chinese Medical College;2003-01
3 QING Fa-ji,YANG Xing-song,ZHAO Hua-qing,LIN Ze-lian(Anhui Province Dingyuan County Hospital of Traditional Chinese Medicine,Anhui Dingyuan 233200,China);Clinical Observation on 48 Cases with Intracerebral Hemorrhage Treated by Jiawei Huanglian Jiedu Decoction[J];Journal of Anhui Traditional Chinese Medical College;2005-05
4 DAI Wen-Bo1, ZHENG Ying-Wei1, MI Xiao-Yi1, LIU Nan1, LIN Hong2, YAN Jun21. Department of Pathology, China Medical University, Shenyang, Liaoning, 110001, P. R. China2. Department of Pathology, The First People's Hospital of Shenyang City, Shenyang, Liaoning, 110041, P. R. China;Expression and Significance of TRAF4 Protein in Breast Carcinoma[J];Chinese Journal of Cancer;2007-10
5 LI Jian-jun1,ZHANG Xiao-Lei2,WANG Xiao-shan2,SUN Qi2,ZHANG Ling-ru2 (1.Department of Neurology,Tianchang People's Hospital,Tianchang Anhui 239300;2.Department of Neurology,Nanjing Brain Hospital,Nanjing Medical University,Nanjing Jiangsu 210029,China);Influence of Ginkgo Biloba Extract on neural cell apoptosis and ultrastructure in ischemic penumbra after cerebral ischemia/reperfusion in rats[J];Journal of Bengbu Medical College;2008-04
6 Ye Huizhou,Zhang Chunxia,Cai Jinzhang The Second Affiliated Hospital of Wenzhou Medical College,Zhejiang(325000),China;Meta-analysis of Comparative Study on Shuxuetong Injection in the Treatment of Acute Cerebral Infarction[J];Journal of Zhejiang University of Traditional Chinese Medicine;2010-05
7 Yang Shijie, Zhou Ming, Xie Xiang lin, Cao Yannian (Department of Pharmacology);EFFECT OF PDS AND PTS ON BLOOD PRESSURE, HEART RATE AND RESPIRATION IN ANAESTHETIZED RATS[J];;1991-01
8 CHEN Sheng wu,WANG Yan,WANG Yi,WANG Li juan,HE Zhong mei,WANG Ben xiang (Jilin Institute of Natural Medicine,TianYao Science and Technology Co.,Ltd,Changchun 130012,China);Study on Anti-Tumor Activity of Ginsenoside Rg_1 and Rh_1[J];Journal of Norman Bethune University of Medical Science;2003-01
9 QIAO Ping, YANG Gui zhen (Dept.of Immunology, School of Basic Medical Sciences, Jilin University, Changchun 130021,China);Effect of Rg1 on learning-memory behavior and immune function in mice treated with D-galactose[J];Journal of Jilin University of (Medicine Edition);2003-03
10 CUI Xin ming 1,LI Yan ru 1,LU Wen wei 2,CUI Li 1,LIU Jie 2 TIAN Jian ming 3,LI Long yun 3,YE Jin mei 3,ZHANG Zhi wei 3,DOU Ying △ (1. Dept.of Electron Microscopy,School of Basic Medical Sciences, Jilin University, Changchun 130021,China;2. Dept.of Pharmacology,School of Basic Medical Sciences, Jilin University;3. Institute of Chinese Traditional Medicine and Herbs,Jilin Province);Protective Effect of Rg_2 on Myocardium of Dog with Acute Cardiogenic Shock[J];Journal of Jilin University of (Medicine Edition);2003-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 CHEN Rui et al(College of Science,Honghe College,Mengzi,Yunnan 661100);Determination of As in Panax notoginseng(Burk.)F.H.Chen by Heteromolybdoarsenic Acid Spectrophotometry[J];Journal of Anhui Agricultural Sciences;2011-08
2 LI Shu-xian,DENG Xiao-hui,LIANG Sheng-wang(School of Traditional Chinese Medicine,Guangdong College of Pharmacy,Guangzhou,Guangdong 510006,China);Optimization of extraction process for liposoluble components from Danxinshu capsules by orthogonal test[J];Journal of Guangdong College of Pharmacy;2008-06
3 HE Qiong~1,TAN Chu-bing~2,ZHAO Qin~1 1.Department of Neurology,Staff Hospital of Xiangtan Steel and Iron Group Co.,Ltd.,Xiangtan 411101,China 2.Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193, China;Clinical observation of Xuesaitong Injection combined with conventional treatment on patients with cerebral infarction[J];Drugs & Clinic;2011-03
4 YANG Tiejun1),HE Chaohong1),CAO Xinguang1),REN Junkai1),CHEN Xiaobing1),WANG Yue2) 1)Department of Urology,Henan Tumor Hospital;the Affiliated Tumor Hospital,Zhengzhou University,Zhengzhou 450008 2)Department of Transplantation,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Protective effects of eirgeron breviscapus(vant) hand-mazz on renal cold ischemia and reperfusion injury in rats[J];Journal of Zhengzhou University(Medical Sciences);2012-02
5 LI Jun,HU Shao-jin.The Fifth Affiliation Hospitals of Zunyi Medical College,Zhuhai 519100,China;The advancement of Chinese medicine prevention renal ischemical reperfusion injury[J];Global Traditional Chinese Medicine;2009-03
6 YANG Yue1,XIE Xi-sheng1,AI Na1,2,WANG Yan-jiang1.1.Department of Nephrology,Nanchong Central Hospital,Nanchong,Sichuan 637001,P.R.China;2.Department of Clinical Medicine,Luzhou Medical College,Luzhou,Sichuan 646000,P.R.China;Research on the Effects and Mechanisms of Astragalus and Radix Notoginseng on Renal Ischemia Reperfusion Injury in Rats[J];West China Medical Journal;2013-04
7 Rong Zhuang Zhi Huiping (Departments of Emergency,Shanghai Shuguang Hospital affiliated to Shanghai University of TCM,Shanghai 200021,China);Case Control Study of Treatment of Acute Cerebral Infarction with Xuesaitong Injection[J];Journal of Neurology and Neurorehabilitation;2008-02
8 DENG Xiang-chao,LI Yan-wu,WANG Ru-jun(Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China);Effect of Total Saponins of Panax notognseng on Gastric Mucosal Lesion and Ultrastructure of Gastric Mucosal Parietal Cells of Stress Rats[J];Lishizhen Medicine and Materia Medica Research;2008-09
9 YANG Ting,JIANG Zan-li,MAO Zu-bin(School of Clinical Medicine,Southeast University,Nanjing 210009,China);Application of xuesaitong in the central nervous system diseases[J];Modern Medical Journal;2010-01
10 Chen Yan, Jinqiang Zhu, Xiaoxu Jia, Chao Wang, Shaoxia Wang, Liyuan Kang Key Laboratory for Prescription of National Educational Ministry of China, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Panax notoginseng saponin attenuates hypoxia/reoxygenation-induced oxidative stress in cortical neurons[J];中国神经再生研究(英文版);2012-36
China Proceedings of conference Full-text Database 1 Hits
1 YIN Li-hu~*,WANG Hong-yu.* Peking University Shougang Hospital Beijing 100144,China;The TCM theory of preventive treatment of disease and early prevention of vascular diseases[A];[C];2013
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved