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《Chinese Traditional and Herbal Drugs》 2006-02
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Effect of Naomaitai Capsule on learning and memory abilities and cerebral lipid-peroxidation in rat with vascular dementia

ZOU Jie-ming~1,LI Yun-man~2,WANG Zheng~1,ZHU Hao-jie~2, ZHOU Jing~2(1.Guilin Sanjin Pharmaceutical Group Limited Company,Guilin 541004,China;2.Department of Physiology,China Pharmaceutical University,Nanjing 210009,China)  
Objective To observe the effect of Naomaitai Capsule on the learning and memory abilities and cerebral lipid-peroxidation in rat with vascular dementia(VD).Methods Two VD models were(established).The first one was produced by occlusion of bilateral common carotid arteries in rats with the(following) steps: ischemia 20 min—reperfusion 10 min—ischemia 20 min.The learning and memory abilities were tested by Y type maze.Meanwhile,malondiadehyde(MDA) content and superoxide dismutase(SOD) activity in brain tissue of ischemia-reperfusion rats were measured.The second model was formed by injecting thrombin NS solution into internal carotid artery.The learning and memory abilities were studied by Y type Maze.The content of Evans blue in brain tissue was measured.Results In the model caused by cerebral ischemia-reperfusion,Naomaitai Capsule significantly improved the learning and memory abilities((P)0.01),increased the activity of SOD(P0.01),and reduced the content of MDA in brain tissue((P)0.05,0.01).In the model caused by multiple cerebral infarction,Naomaitai Capsule significantly improved the learning and memory abilities(P0.05,0.01) and reduced the content of Evans blue in brain tissue(P0.01).Conclusion Naomaitai Capsule can improve the learning and memory abilities of the rats with VD and reduce the injury caused by cerebral lipid peroxidation
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 4 Hits
1 ;脑脉泰胶囊对血管性痴呆患者认知功能障碍的康复作用[J];China Medical Herald;2006-29
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Zhang Zunquan (Institute of Materia Medica Hunan Academy of TCM, Hunan);Influences of the Prescription of Jiannao Tonluo Capsule on Neurotransmitter in Rat Models of Dementia[J];China Journal of Traditional Chinese Medicine and Pharmacy;2000-01
2 Zou Jieming et al (Guilin Sanjin Pharmaceutical Com. Ltd. );Pharmacodynamic and Toxicologic Research on Nao Mai Kang Capsule[J];China Journal of Traditional Chinese Medicine and Pharmacy;2003-07
3 Liu Ping 1,Wang Jinliang 1,Wang Yan 2,et al (1Pharmacology Department, General Hospital of PLA;2College of Chinese Materia Medica, Capital University of Medicine Sciences);Study on Dosage Application of Herbs in Class Formulas of KaixinSan and Their Actions on Depression[J];China Journal of Traditional Chinese Medicine and Pharmacy;2005-05
4 wangjian, et al;Effection of blood vigor of SOD on mice treated by single ginseny and Ding Zhi Xiao wan[J];;1994-03
5 ;Methodological evaluation of the studies of vascular dementia[J];Acta Academiae Medicinae Militaris Tertiae;2004-17
6 MIAO Jian Ting, LI Zhu Yi, LIN Hong, LEI Ge Sheng, LI Hong Zeng, SU Chang Jun, ZHU Lin, YOU Guo Xiong Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China;Oxidative stress induced by β-amyloid peptide in pathogenesis of Alzheimer's disease in rats[J];Journal of The Fourth Military Medical University;2001-15
7 FANG Ling, WANG Ning, WU Zhi\|ying, LIN Min\|ting, MURONG Shen\|xing (Department of Neurology, The First Affiliated Hospital, Fujian Medical University, Fuzhou\ 350005, China) \ \;Relationship between Nitric Oxide Synthase and Neuronal Damage at the Subacute Stage of Focal Cerebral Ischemia[J];Journal of Fujian Medical University;2003-01
8 Cai Jing,Du Jian;Changes of Serum Levels of ET,CGRP,NO in Patients with Vascular Dementia[J];Fujian Meidical Journal;2001-02
9 Dai Enlai~(1),Ou Xiumei~(2),Ma Hongbin~(2),Sun Hongxu~(1)(1.Gansu College of TCM,730000,Lanzhou,China;2.The Affiliated Hospital of Gansu College of TCM,730020,Lanzhou,China);Experimental study of Tongluo Yizhi Powder's effect on Glu and GABA in the brain tissue of rats with vascular dementia[J];Journal of Gansu College of Traditional Chinese Medicine;2006-03
10 Zhang Yongquan Lu Hui Liu TaiThe Second Affiliated Hospital, Guangxi University of TCM Nanning 530011;Effect of Fu Nao Ling In-Take Liquid on Intelligence and Super-oxide Dismutase in Patients of Vascular Dementia due to Phlegm Stagnancy[J];Guangxi Journal of Traditional Chinese Medicine;2001-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Hai-Ning,SUN Li,TANG Yue-Yu,WANG Ming-Yu,WU Jiang.Department of Neurology,First Hospital,Jilin University,Changchun 130021,China;Effects of Naomaitai Capsule on cerebral blood flow and apoptosis of hippocampus neuron in rats with vascular dementia induced by chronic forebrain ischemia[J];Journal of International Neurology and Neurosurgery;2009-04
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