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《Chinese Traditional and Herbal Drugs》 2006-02
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Effect of Naomaitai Capsule on learning and memory abilities and cerebral lipid-peroxidation in rat with vascular dementia

ZOU Jie-ming~1,LI Yun-man~2,WANG Zheng~1,ZHU Hao-jie~2, ZHOU Jing~2(1.Guilin Sanjin Pharmaceutical Group Limited Company,Guilin 541004,China;2.Department of Physiology,China Pharmaceutical University,Nanjing 210009,China)  
Objective To observe the effect of Naomaitai Capsule on the learning and memory abilities and cerebral lipid-peroxidation in rat with vascular dementia(VD).Methods Two VD models were(established).The first one was produced by occlusion of bilateral common carotid arteries in rats with the(following) steps: ischemia 20 min—reperfusion 10 min—ischemia 20 min.The learning and memory abilities were tested by Y type maze.Meanwhile,malondiadehyde(MDA) content and superoxide dismutase(SOD) activity in brain tissue of ischemia-reperfusion rats were measured.The second model was formed by injecting thrombin NS solution into internal carotid artery.The learning and memory abilities were studied by Y type Maze.The content of Evans blue in brain tissue was measured.Results In the model caused by cerebral ischemia-reperfusion,Naomaitai Capsule significantly improved the learning and memory abilities((P)0.01),increased the activity of SOD(P0.01),and reduced the content of MDA in brain tissue((P)0.05,0.01).In the model caused by multiple cerebral infarction,Naomaitai Capsule significantly improved the learning and memory abilities(P0.05,0.01) and reduced the content of Evans blue in brain tissue(P0.01).Conclusion Naomaitai Capsule can improve the learning and memory abilities of the rats with VD and reduce the injury caused by cerebral lipid peroxidation
【CateGory Index】: R285.5
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1 ;脑脉泰胶囊对血管性痴呆患者认知功能障碍的康复作用[J];China Medical Herald;2006-29
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8 Cai Jing,Du Jian;Changes of Serum Levels of ET,CGRP,NO in Patients with Vascular Dementia[J];Fujian Meidical Journal;2001-02
9 Dai Enlai~(1),Ou Xiumei~(2),Ma Hongbin~(2),Sun Hongxu~(1)(1.Gansu College of TCM,730000,Lanzhou,China;2.The Affiliated Hospital of Gansu College of TCM,730020,Lanzhou,China);Experimental study of Tongluo Yizhi Powder's effect on Glu and GABA in the brain tissue of rats with vascular dementia[J];Journal of Gansu College of Traditional Chinese Medicine;2006-03
10 Zhang Yongquan Lu Hui Liu TaiThe Second Affiliated Hospital, Guangxi University of TCM Nanning 530011;Effect of Fu Nao Ling In-Take Liquid on Intelligence and Super-oxide Dismutase in Patients of Vascular Dementia due to Phlegm Stagnancy[J];Guangxi Journal of Traditional Chinese Medicine;2001-02
【Secondary References】
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1 ZHANG Hai-Ning,SUN Li,TANG Yue-Yu,WANG Ming-Yu,WU Jiang.Department of Neurology,First Hospital,Jilin University,Changchun 130021,China;Effects of Naomaitai Capsule on cerebral blood flow and apoptosis of hippocampus neuron in rats with vascular dementia induced by chronic forebrain ischemia[J];Journal of International Neurology and Neurosurgery;2009-04
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