Thinking mode and practice of study on newly-developed drug of Chinese materia medica
ZHANG Tie-jun (Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China)
To study the newly-developed drug of Chinese materia medica (CMM) for clinic use is an intricate systematical engineering with multi factors between subject and object, such as the theoretical system of disciplines, the objects of study, and the consumers of the drug. The characters, advantages, and deficiency in the simple systematic theory of traditional Chinese medicine (TCM), the reductionism of the western medicine in the latter days, and the modern systematology of the neoteric TCM. Base on the view point of systematical thinking mode for study on new drug of CMM used for clinic, the forming process of CMM is divided into three stages, they are the formation of raw medicinal materials, the preparation of the drug, and the in vivo metabolism of the drug, among every stages each factor is analyzed. The thinking mode and the research method explored for the newly-developed drug of CMM are put forward by the above-mentioned rational knowledge. The focuses and key problems in the study are approached in scientific practice. Finally an argument on this topic is set fourth. That is, applying the thinking mode to observing the interference rule of CMM on diseases in clinic from various sides of life movement in an integrity, common relation, and varied way by means of the verified experimental measure and systematic analysis method. Acting on the principle of combining the inheritance with the innovation, keeping on developing what is useful and healthy, and discarding what is not in TCM, the modern CMM will be degenerated and obtained in a completely new sense.
【CateGory Index】： R28