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Stability of traditional Chinese medicinal materials′ quality adhered to regularity of biogenetic polymorphism

HE Fu-yuan1,2, ZHOU Hong-hao1, LUO Jie-ying1, LIU Ta-si2, DENG Kai-wen3(1. Institute of Clinical Pharmacology, Central South University, Changsha 410078, China; 2. School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410007, China; 3. The First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha 410007, China)  
Objective To analyze the scientific contexts that the quality control of traditional Chinese medicinal materials (TCMM) is abided by biogenetic polymorphic regularity, according to the principle of genetics, pharmacogenetics, molecular biology, and natural pharmacodynamic mechanism in Chinese materia medica (CMM), as well as combining with the property of the traditional Chinese medicine (TCM). Simultaneously to point out the modernization model of quality control and the method of TCMM, followed by the thoughts and requirements of CMM′s modernization. Compared with the western medicine, CMM, as an integer, carried out with the original biogenetic polymorphic information, synthesized out under primary and secondary metabolic enzymes, especially CYP450 enzymes, imported into human body, and metabolized by these enzymes, takes place the inductive, inhibitive, and irreversible reaction at the end with receptors, which is similar to the metabolic enzymes in primary channels of human being and impersonated with the "counter-treatment and complementation" effects in TCM theoretical term. The deficient patients treated by reinforcing CMM, as well as the conversion action, and the "co-network compatibility and rainbow potency" regularity by mass law, as a result from the duple pharmacogenetic reaction. The stability research on the quality control of TCMM must obey to the biogenetic polymorphism rules and the personal administration in pharmacogenetics. The information entropy varied with different regions, expressed by the curve of normal probability distribution as two parameters of the mean and variance for every original plant strains. There is a stable quality in colonials of the Hard-Weinberg equilibrium of TCMM.
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