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《Chinese Traditional and Herbal Drugs》 2008-01
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Stability of traditional Chinese medicinal materials′ quality adhered to regularity of biogenetic polymorphism

HE Fu-yuan1,2, ZHOU Hong-hao1, LUO Jie-ying1, LIU Ta-si2, DENG Kai-wen3(1. Institute of Clinical Pharmacology, Central South University, Changsha 410078, China; 2. School of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410007, China; 3. The First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha 410007, China)  
Objective To analyze the scientific contexts that the quality control of traditional Chinese medicinal materials (TCMM) is abided by biogenetic polymorphic regularity, according to the principle of genetics, pharmacogenetics, molecular biology, and natural pharmacodynamic mechanism in Chinese materia medica (CMM), as well as combining with the property of the traditional Chinese medicine (TCM). Simultaneously to point out the modernization model of quality control and the method of TCMM, followed by the thoughts and requirements of CMM′s modernization. Compared with the western medicine, CMM, as an integer, carried out with the original biogenetic polymorphic information, synthesized out under primary and secondary metabolic enzymes, especially CYP450 enzymes, imported into human body, and metabolized by these enzymes, takes place the inductive, inhibitive, and irreversible reaction at the end with receptors, which is similar to the metabolic enzymes in primary channels of human being and impersonated with the "counter-treatment and complementation" effects in TCM theoretical term. The deficient patients treated by reinforcing CMM, as well as the conversion action, and the "co-network compatibility and rainbow potency" regularity by mass law, as a result from the duple pharmacogenetic reaction. The stability research on the quality control of TCMM must obey to the biogenetic polymorphism rules and the personal administration in pharmacogenetics. The information entropy varied with different regions, expressed by the curve of normal probability distribution as two parameters of the mean and variance for every original plant strains. There is a stable quality in colonials of the Hard-Weinberg equilibrium of TCMM.
【CateGory Index】: R282
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【References】
Chinese Journal Full-text Database 2 Hits
1 HUANG Sheng~1,HE Fu-yuan~(1,2),LIU Wen-long~1,LI Qi-quan~1,JIANG Huan-ying~1,NIE Zhi-jiao~1,LUO Jie-ying~1(1.Department of Pharmaceutics,Hunan University of Traditional Chinese Medicine,Changsha 410208,China;2.Pharmacogenetic Research Institute,Central South University,Changsha 410078,China);Evaluation of release similarity of multicomponents in Zuojin Sustained-Release Tablet by the total quantum statistical moment similarity[J];Chinese Traditional Patent Medicine;2009-01
2 WANG Zhan-guo1, HU Hui-ling2, LAN Ke1,JIANG Xue-hua1(1. West China College of Pharmacy, Sichuan University, Chengdu 610041, China; 2. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China);Application of PK-PD methods based on metabonomics and "FANG-ZHENG Correspondence" to investigating compatibility of Chinese material medica[J];Chinese Traditional and Herbal Drugs;2009-02
【Citations】
Chinese Journal Full-text Database 5 Hits
1 XU Fu min(College of Harbour Waterway and Coastal Engineering, Hohai Univ., Nanjing 210098, China);Application of Maximum Entropy Principle Method in Wave Height Distribution[J];JOURNAL OF HOHAI UNIVERSITY;2000-01
2 He Fuyuan, Luo Jieying and Liu Wenlong ( School of Chinese Materia Medica, Hunan Institute of Traditional Chinese Medicine, Changsha 410007 ) Deng Kaiwen ( The First Hospital Affiliated to Hunan Institute of Traditional Chinese Medicine, Changsha 410007 );Preliminary Exploration of Orientation and Method of Chromatographic Pharmacodynamics of Traditional Chinese Medicine[J];;2004-06
3 Wang Jie(Guanganmen Hospital, China Academy of Traditional Chinese Medicine, Beijingl00052) Guo Lili and Yang Ge (Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091) Wang Yongyan (China Academy of Traditional Chinese Medicine, Beijing 100070);Methodology and Prospects of Study on Theory of Compatibility of Prescriptions in Traditional Chinese Medicine[J];;2006-01
4 Xiao-Lin Yu, Jia-Shu Cao, Hui-Mei Cui, Wan-Zhi Ye (Department of Horticulture, College of Agri-Biotechnology of Zhejiang University; The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development & Biotechnology, Hangzhou 310029, China);Plant Cytochrome P450[J];Chinese Journal of Coll Biology;2004-06
5 Huang Ya (The Research Institute of Medicine Plantation of Chongqing, Nanchuan,Chongqing 408435);The Standardization Produce of Chinese Traditional Medicine and the Actuality of the Attestation's Development[J];Asia-Pacific Traditional Medicine;2006-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHONG Wei-ran et al (College of Agronomy and Biotechnology,Southwest University,Chongqing 400716);Study on the Cytochrome P450s in Phenylpropanoid Metabolic Pathway[J];Journal of Anhui Agricultural Sciences;2008-13
2 ZHANG Song-huan et al(College of Life Sciences,Henan Agricultural University,Zhengzhou,Henan 450002);Cloning Strategies and Identification Methods of Plant Cytochrome P450 Gene[J];Journal of Anhui Agricultural Sciences;2009-11
3 TU Sheng-hao,SHENG Dong-yun, XIONG Ri-bo,HU Yong-hong(The Department of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Wuhan 430030,China);The Inhibitory Effect of Triptolide on Interleukin-1β Production by PBMC from RA Patients with the Gene Polymorphisms of Interleukin-1β[J];Journal of Anhui Traditional Chinese Medical College;2006-03
4 YANG Xiu wei, ZHAO Jing, CUI Jing rong △, GUO Wei (State Key Laboratory of Natural & Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100083, China);Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin I[J];Journal of Peking University(Health Sciences);2004-01
5 YANG Xiu-wei1,2, ZHANG Jian-ye1, XU Wei1(1. Department of Natural Medicines, 2. State Key Laboratory of Natural & Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100083, China);Biotransformation of mogroside Ⅲ by human intestinal bacteria[J];Journal of Peking University(Health Sciences);2007-06
6 Zhao Yu-Feng1,2,Song Feng-Rui1,Yue Hao1,Guo Xin-Hua1,Li Hui-Lin1,Liu Zhi-Qiang1,Liu Su-Ying*11(Changchun Institute of Applied Chemistry,Chinese Academy of Sciences, Changchun 130022)2(Graduate School of the Chinese Academy of Sciences,Beijing 100039);Studies on the Biotransformation of 16-O-demethyldeoxyaconitine of the Metabolite of Aconitine in Human Intestinal Bacteria[J];Chinese Journal of Analytical Chemistry;2007-12
7 WANG Xue-zhi1,2,YANG Zhi-qiang2,LI Jian-xi2,ZHU Xin-shu2,ZHANG Kai2,MENG Jia-ran2,ZHANG Yan2(1.College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China;2.Lanzhou Institute of Animal Sciences and Veterinary Pharmaceutics of CAAS,Lanzhou 730050,China);Study on the interaction between the coarse polysaccharide in fermentation complex of Astragalus and the probiotics isolated from chicken intestine[J];Journal of Gansu Agricultural University;2008-06
8 ZHANG Zhen-quan Nanjing College of Traditional Chinese Medicine,Jiangsu Nanjing China 210029;A Teview of the Theory of Prescription Compatibility[J];Gansu Journal of Traditional Chinese Medicine;2009-05
9 ZHANG Liang-deng1,2,WANG Jie1,HE Qing-yong1 (1Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;2School of Acupuncture and Moxibustion,Beijing University of Chinese Medicine,Beijing 100029,China);Study advance of Chinese herbal components compatibility in treating angina pectoris[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-06
10 Ning Shuju Wei Daozhi Xu Guanyin (Department of Agronomy Handan Agricultural College Hebei Yongnian 057150);Bio-Microarray Technique and Application[J];Journal of Handan Agricultural College;2003-01
China Proceedings of conference Full-text Database 8 Hits
1 HU Jie,LIU Xiao-jie,QIN Xue-mei,ZHANG Li-zeng,GUO Xiao-qin(School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China;);Optimization of acid conditions for HPLC determination of Saikosaponin and evaluation on related methods[A];[C];2008
2 ;双向发酵对白芍HPLC指纹图谱及芍药苷含量的影响[A];[C];2008
3 ;中草药生物转化工程与中医药创新[A];[C];2009
4 HE Fu-yuan~(1,2) DENG Kai-wen~3 SHI Ji-lian~1 LIU Weng-long~2 LIU Ping-an~1 ZHOU Honghao~1 (1.Pharmacogenetic Research Institute,central South university Changsha(410078);2.Department of Pharmaceutics,Hunan University of Tradition Chinese Medicine Changsha(410208);3.The First Affinity Hospital,Hunan University of Tradition Chinese Medicine Changsha(410007) China);Study of the Chromatodynamics,A Pharmacodynamic Approach for the CMMF with Fingerprint Chromatrography and Validation of Herba Houttuyniae Injection[A];[C];2009
5 ;Study on the variant Relationship between genetic polymorphism and Chromatographic Fingerprints of volatile oil to Herba Houttuyniae[A];[C];2009
6 ;Study of the Chromatodynamics,A Pharmacodynamic Approach for the Validation of Herba Houttuyniae Injection[A];[C];2009
7 Fu-Yuan He~(1,2),DENG Kaiwen~3 ZOU Huan~2 QIU Yun~2 CHENG Feng~2 Hong-Hao Zhou~1 (1.Pharmacogenetic Research Institute,Institute of Clinical Pharmacology,Central South University Changsha(410078);2 Department of Pharmaceutics,Hunan University of Tradition Chinese Medicine Changsha(410208)) 3.The First Affinity Hospital,Hunan University of Tradition Chinese Medicine Changsha(410007),China);Study on the Differences between Chromatokinetics and Chromatodynamics with Fingerprint Chromatography[A];[C];2009
8 ZHANG Jun-qing,FU Nai-guang,Tan Yin-feng,Liu Ming-sheng (Department of Pharmacy,Hainan Medical College,Hainan Provincial Key Laboratory of R&D of Tropical Herbs,Haikou 571101,China);Determination of Nimbecetin Metabolites in Rat Plasma by Liquid Chromatography-Mass Spectrometry[A];[C];2009
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WU Shi shan (Center of Research on Surface & Interface Chemical Engineering & Technology, Nanjing University, Nanjing 210093, China);STUDY ON SOLUTION PARAMETER OF STYRENE-BUTADIENE RUBBER[J];Polymeric Materials Science & Cngineering;2002-04
2 Li Shufen;Chen Baoliang;Han Jinyu(Department of Chemical Engineering,Tianjin University,Tianjin,300072);Special Features of Processing Natural Products with Supercritical CO_2,[J];Chemical Industry and Engineering Progress;1997-02
3 XU Fu min(College of Harbour Waterway and Coastal Engineering, Hohai Univ., Nanjing 210098, China);Application of Maximum Entropy Principle Method in Wave Height Distribution[J];JOURNAL OF HOHAI UNIVERSITY;2000-01
4 Wang Kang,Zhang Xiaolin,Xue Weiming,Kang Maode(Chemical Engineering Department of Northwest University,Xi′an 710069);Study on Extracting Process of  Effective Components from Cacumen Biotae[J];CHEMICAL ENGINEERING(CHINA);1998-03
5 Shang Hongcai , Li Shao , Gao Xiumei, et al.(TCM Research Center, Tianjin College of Traditional Chinese Medicine, Tianjin 300193);Multi-Objective and Fuzzy Optimization of the Different Ratios of Danshen (Salvia miltiorrhiza) to Sanqi (Panax notoginseng) in Composing Formulas[J];Journal of Beijing University of Traditional Chinese Medicine;2003-04
6 Yan Yongqing (China Pharmaceutical University Nanjing 210009);Synergism Factors of Material Base in Compound Prescription of Traditional Chinese Medicine[J];World Science and Technology;2001-02
7 Liang Yizeng(Re search Center of Modernization of Chinese Herbal Medicines,Central South Univer sity,Changsha410083)Xie Peishan (Guangzhou Institute for Drug Control, Guanzghou510160);Chemical pattern recognition of fingerprint of Traditional Chinese Medicines---Exploration of Several substantial Issues to be solved(3)[J];;2002-05
8 He Fuyuan, Luo Jieying and Liu Wenlong ( School of Chinese Materia Medica, Hunan Institute of Traditional Chinese Medicine, Changsha 410007 ) Deng Kaiwen ( The First Hospital Affiliated to Hunan Institute of Traditional Chinese Medicine, Changsha 410007 );Preliminary Exploration of Orientation and Method of Chromatographic Pharmacodynamics of Traditional Chinese Medicine[J];;2004-06
9 He Fuyuan Luo Jieying (Hunan University of Tradition Chinese Medicine) Den Kevin (No.1 Hospital affiliated to Hunan University of Tradition Chinese Medicine, Changsha 410007 ,China);A Study of Total Amount Statistic Moment for TCM Pharmacokinetics[J];;2006-06
10 Qi Lianwen Li Ping Zhao Jing Key Laboratory of Modem Chinese Medicines, Ministry of Education, and Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, China;Metabonomics and Modernization of TCM Research[J];;2006-06
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 HE Fu-yuan1,2,DENG Kai-wen3,WU De-zhi2,LIU Wen-long2,LIU Ping-an2,ZHOU Hong-hao1(1.Pharmacogenetic Research Institute,Central South University,Changsha,410078;2.Department of Pharmaceutics,Hunan University of Traditional Chinese Medicine,Changsha,410208;3.No.1 Hospital Affiliated to Hunan University of Traditional Chinese Medicine,Changsha,410007 China);Extraction kinetical deviations of berberine alkaloids in Rhizoma Coptidis and Zuojin Formulae[J];Chinese Traditional Patent Medicine;2009-09
2 HUANG Xi1,2,3,FAN Rong1,2,3,ZHANG Hai-nan1,2,3,REN Ping2,4,QIN Feng1,2,3,WANG Yang1,2,3(1. Institute of Integrated Traditional Chinese Medicine and Western Medicine,Xiangya Hospital,Central South University,Changsha 410008,China;2. Key Unit of Gan-Zangxiang Related Disease,State Administration of Traditional Chinese Medicine(SATCM),Xiangya Hospital,Central South University,Changsha 410008,China;3. Key Unit of the 11th Five-year Plan of SATCM in Cerebrosis,Xiangya Hospital,Central South University,Changsha 410008,China;4. Department of Pharmacy,Xiangya Hospital,Central South University,Changsha 410008,China);Bioethnopharmaceutical analytical pharmacology:a strategy for elucidating ethnoherbal absorbed bioactive compounds[J];Chinese Traditional and Herbal Drugs;2010-03
3 CHEN Li-hong1,2,TANG Yu-ping1,WANG Qiang3(1.Jiangsu Key Laboratory for Traditional Chinese Medicine Formula Research,Nanjing University of Traditional ChineseMedicine,Nanjing 210046,China; 2.College of Pharmacy,Nanjing Univsity of Traditional Chinese Medicine,Nanjing 210046,China; 3.Department of Chinese Materia Medica Analysis,China Pharmaceutical University,Nanjing 210009,China);Advances in studies on Gegen Qinlian Decoction[J];Chinese Traditional and Herbal Drugs;2010-04
China Proceedings of conference Full-text Database 4 Hits
1 HE Fu-yuan~(1,2) DENG Kai-wen~3 SHI Ji-lian~1 LIU Weng-long~2 LIU Ping-an~1 ZHOU Honghao~1 (1.Pharmacogenetic Research Institute,central South university Changsha(410078);2.Department of Pharmaceutics,Hunan University of Tradition Chinese Medicine Changsha(410208);3.The First Affinity Hospital,Hunan University of Tradition Chinese Medicine Changsha(410007) China);Study of the Chromatodynamics,A Pharmacodynamic Approach for the CMMF with Fingerprint Chromatrography and Validation of Herba Houttuyniae Injection[A];[C];2009
2 ;Study of the Chromatodynamics,A Pharmacodynamic Approach for the Validation of Herba Houttuyniae Injection[A];[C];2009
3 ;Studies on Metabolic differences between original compounds and metabolites for Herba Houttuyniae Injection[A];[C];2009
4 Fu-Yuan He~(1,2),DENG Kaiwen~3 ZOU Huan~2 QIU Yun~2 CHENG Feng~2 Hong-Hao Zhou~1 (1.Pharmacogenetic Research Institute,Institute of Clinical Pharmacology,Central South University Changsha(410078);2 Department of Pharmaceutics,Hunan University of Tradition Chinese Medicine Changsha(410208)) 3.The First Affinity Hospital,Hunan University of Tradition Chinese Medicine Changsha(410007),China);Study on the Differences between Chromatokinetics and Chromatodynamics with Fingerprint Chromatography[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 Xu Honghua (Guangzhou University of Traditional Chinese Medicine);Implement on GAP of Chinese Material Medica and Promote the Modernization of Traditional Chinese Medicine[J];World Science and Technology;2001-01
2 Luo Guoan,Wang Yiming,Cao Jin and Yang Xuedong(Institute of Pharmaceutical Science,Tsinghua University);Studies on Establishment of Modern Quality Standards System of Traditional Chinese Medicine in China[J];;2002-04
3 ZHAO Jian;YANG Wen-Jie;ZHU Wei-Hua;(Institute of Materia Medica, Chinese Academy of Medical Science, Beijing 100050*College of Life Science,Northeast Normal University,Changchun 130024);Cytochrome P450 and plant secondary metabolism[J];CHINESE BULLETIN OF LIFE SCIENCES;1999-03
4 LIU Chaoshen1, WANG Dongmei1, BAI Jie2, YANG Depo1,2(1. Laboratory of Pharmacognosy and Natural Pharmaceutical Chemistry, School of Pharmacy, Zhongshan University, Guangzhou 510275, China; Science, Zhongshan University, Guangzhou 510275, China);Application of Chromatography in Fingerprint Study of Chinese Traditional Medicine[J];Chinese Journal of Chromatography;2003-06
5 Ning Lili, Bi Kaishun, Wang Rui, Che Zhentao 1, Wang Xi and Luo Xu (Shenyang Pharmaceutical University, Shenyang 110015; 1Department of Chemistry, Hong Kong University of Science and Technology, School of Chinese Medicine, the Chinese Univer;METHODOLOGICAL STUDY ON THE MATERIAL BASIS FOR THE EFFICACY OF THE TRADITIONAL CHINESE MEDICINE WUZHUYU DECOCTION[J];ACTA PHARMACEUTICA SINICA;2000-02
6 Wang Chao Zhang Xinong Zhang Jinghui (Xi'an Jiaotong University);THE INFORMATION QUANTITY AND MAXIMUM ENTROPY PROBABILITY ESTIMATION METHOD IN RANDOM VIBRATLON[J];Chinese Journal of Applied Mechanics;1989-02
7 JIANG Wen yue (Department of Integrated Chinese Traditional with Western Medicine, Modern Research Center for TCM, Peking University, Beijing 100083, China);No key relevant to modernization of Chinese materia medica by searching efficacy substance[J];Chinese Traditional and Herbal Drugs;2003-01
8 LUO Guo-an,WANG Yi-ming (Medicinal Institute of Tsinghua University,Beijing 100084,China);Classification and Development of TCM Fingerprint[J];Chinese New Drugs Journal;2002-01
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