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Physico-chemical property of submicron emulsion prepared by phase inversion-ultrasound emulsifying technology

YOU Rong-hui1,2, YUAN Hai-long1, YANG Ming2, YUE Peng-fei1,2, XIAO Xiao-he1(1. 302 Hospital of PLA, PLA Institute of Chinese Materia Medica, Beijing 100039, China; 2. Key Laboratoryof Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi Collegeof Traditional Chinese Medicine, Nanchang 330004, China)  
Objective To study the physico-chemical property of the submicron emulsions containing Oleum Curcumae Wenchowensis by emulsion phase inversion-ultrasound technology and the high-pressure emulsionizing technology. Methods The submicron emulsion was prepared by emulsion phase inversion-ultrasound technology and high-pressure emulsionizing technology, respectively. The morphous, particle diameter distribution, drug content, and stability of the formed emulsion were investigated. Results The particle diameter distributions of emulsion prepared by emulsion phase inversion-ultrasound and high-pressure emulsionizing technology were 188.14, and 277.78 nm, respectively. The drug contents were 9.240 1 and 8.743 6 mg/mL, respectively. The stability of emulsion was enhanced markedly by the phase inversion-ultrasound technology. Conclusion Compared with the high-pressure emulsionizing technology, the phase inversion-ultrasound technology is a stable and easily preparation and does enhance the stability and targeting of submicron emulsion.
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