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Preparation and capability evaluation of oral microemulsion silybin

JIANG Lai1, LIU Huan2, WANG Chun-long2, QIAO Jian-jun1(1. School of Chemical Engineering and Technology of Tianjin University, Tianjin 300072, China;2. Tianjin Institute of Pharmaceutical Research,Tianjin 300193, China)  
Objective To prepare stable silybin oral microemulsion. Methods The formulation of the silybin oral microemulsion was optimized by the combination of surface tension measure, pseudo-ternary phase diagram drawing and orthogonal design. Results Microemulsion type was identified. Average particle diameter was measured. Distribution of silybin in microemulsion was measured by ultracentrifugation. The centrifugalization and influencing factors experiment of microemulsion were carried out,which could keep homogeneous and stable for three months on the storage condition of room temperature. Meanwhile,the influence of high-temperature and illumination was a little. Conclusion Stable oral microemulsion silybin can be prepared in this formulation, with fine-looking and desirable stability which is better for the further studies.
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