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Blood lipid regulation of ethyl acetate extracting fraction and stilbene glycoside from tuber of Polygonum multiflorum

WANG Chun-ying, ZHANG Lan-tong, YUAN Zhi-fang, JIN Yi-bao, ZHANG Zheng(Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China)  
Objective To investigate the blood lipid regulation of ethyl acetate extracting fraction from the tube of Polygonum multiflorum (EAEF-PM) and stilbene glycoside from the tuber of P. multiflorum. Methods The effects of EAEF-PM and stilbene glycoside on blood lipid and liver index were studied in normal mice. Acute hyperlipidemic model mice induced by ip Triton as markers were used to observe the effects of EAEF-PM and stilbene glycoside on the blood lipid level. The investigation was also employed in the hyperlipidemic model rats induced by feeding with the high-lipid diet accompanied by ig EAEF-PM and stilbene glycoside for 28 d, respectively. The effects of EAEF-PM and stilbene glycoside were studied by measuring the concentrations of lipids, malondialdehyde (MDA), nitric oxide (NO), and the activity of superoxide dismutase (SOD) in serum of the hyperlipidemic rats. The levels of total cholesterol (TC) and triglyeride (TG) in liver as well as liver index were also simultaneously determined. Results In the normal mice, EAEF-PM and stilbene glycoside not only increased the level of serum high density lipoprotein cholesterol (HDL-C), also decreased the level of serum low density lipoprotein cholesterol (LDL-C). EAEF-PM and stilbene glycoside lowered serum TC, TG and LDL-C, and increased serum HDL-C in the hyperlipidemic mice. Administration of EAEF-PM (60 mg/kg) could signi-ficantly reduce the liver index in hyperlipidemic rats. Administration of EAEF-PM (30 and 60 mg/kg) could remarkably decrease the levels of serum TC, TG, LDL-C as well as the ratio of TC/HDL-C, also remarkably increase serum HDL-C, NO, and SOD. Compared with EAEF-PM, stilbene glycoside had the somewhat lower effect but no significant difference. Conclusion EAEF-PM and stilbene glycoside possess the obvious effects of blood lipid-regulation, antioxidation and protecting vascular endothelium. The potential constituent is stilbene glycoside which can be used to prevent and/or treat hyperlipidemia.
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