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《Chinese Traditional and Herbal Drugs》 2008-02
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Preparation of β-elemene solid lipid nanoparticles by film-ultrasonic wave dissolving techniques

LIU Hong-mei,CHU Hui-yuan,CUI Jin-xia,WU Lin-hua(Department of Pharmacy,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China)  
Objective To prepare β-elemene solid lipid nanoparticles and investigate their particle size diameter and entrapment efficiency.Methods The β-elemene solid lipid nanoparticles were prepared by film ultrasonic wave dissolving techniques.And the optimum formula was selected through orthogonal design test according to the entrapment efficiency.Results The optimizing technique was β-elemene(20 μL),stearic acid(90 mg),lecithin(90 mg),Tween80(2.5 %,5 mL) and Poloxamer 188(2.5 %,5 mL).Conclusion The technique of preparing β-elemene by film-ultrasonic wave dissolving technique is feasible.
【CateGory Index】: R284.1
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