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《Chinese Traditional and Herbal Drugs》 2008-02
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Antitumor effects of neogambogic acid both in vivo and in vitro

CHENG Hui,PENG Dai-yin,WANG Xiao-shan,TANG Li-jian,HUANG Peng,LI Qing-lin(Anhui Key Laboratory of Modern Chinese Materia Medica,Anhui College of Traditional Chinese Medicine,Hefei 230038,China)  
Objective To investigate the antitumor effects of neogambogic acid both in vivo and in vitro.Methods Cancer cell lines were incubated with various concentrations of neogambogic acid for 24,48,and 72 h,antiproliferative activities against cancer cells were measured by MTT assay;The BALB/c-nude mice were transplanted with cancer cells,then iv by 4,8,16,and 32 mg/kg neogambogic acid,the size and weight of the tumor were measured.Results Neogambogic acid could inhibit the proliferation of cancer cell lines(human colon carcinoma HCT-8 cell,human hepatoma Bel-7402 cell,human gastric carcinoma BGC-823 cell,human non-small cell lung cancer A549 cell,and human ovarian cancer A2780 cell).The 50% inhibiting concentration(IC50) of neogambogic acid of 72 h was from 1.75 to 3 μmol/L.It also showed the inhibition on the growth of A549 in nude mice at the doses of 8,16,and 32 mg/kg of neogambogic acid intravenously(P0.05).However neogambogic acid did not show the obvious inhibition on the growth of tumor Bel-7402 at the dose from 4 to 16 mg/kg.Conclusion It suggests that neogambogic acid has the inhibitory effects on the proliferation of human cancer cell lines in vitro and on the tumor growth of nude mice transplanted with A549 cell in vivo.
【Fund】: 安徽省自然科学基金资助项目(070413128);; 安徽省科技攻关重点项目(06013131B)
【CateGory Index】: R285
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