Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Traditional and Herbal Drugs》 2008-02
Add to Favorite Get Latest Update

Protection and mechanism of total flavones from Rhododendron simsii on myocardial ischemia-reperfusion injury rats

FAN Yi-fei1,WANG Yun-hai2,ZHANG Jian-hua3,CHEN Zhi-wu3(1.Department of Physiology,Anhui Medical University,Hefei 230032,China;2.Department of Chest Surgery,First Affiliated Hospital,Anhui Medical University,Hefei 230032,China;3.Department of Pharmacology,Anhui Medical University,Hefei 230032,China)  
Objective To study the protective effect of total flavone from Rhododendron simsii(TFRS) on myocardial ischemia-reperfusion injury rats and its mechanism.Methods The ischemic model was made by occluding the anterior descending of the left artery(LAD) in rats.The change of ST segment and T wave of electrocardiograph(ECG) were observed,and the activity of lactate dehydrogenase(LDH),creatine kinase(CK),levels of the maleic dialdehyde(MDA),and nitric oxide(NO) in serum were measured.And by tetrazolium chloride(TTC) staining,the areas of myocardial infarction were observed.The expression of inducible nitricoxide synthase(iNOS) in rats was detected by emploring the reverse transcription-polymerase chain reaction(RT-PCR) technique.Results On the myocardial infarction model by occluding the anterior descending of the LAD in rats,TFRS(100 mg/kg) obviously reduced the height of ST segment after occluding 30 min and TFRS(25,50,and 100 mg/kg) obviously reduced the height of ST segment after reperfusion 30 min.TFRS(50 mg/kg) reduced by myocardial infarction area.TFRS(50 and 100 mg/kg) obviously reduced the activity of CK and LDH.TFRS(50 mg/kg) decreased the level of MDA in serum.By RT-PCR technique,it was found that the expression of iNOS mRNA in myocardium in IR rats pretreated with TFRS(100 mg/kg) was higher than that in IR and normal groups.Conclusions TFRS has the significant protection against myocardial ischemia-reperfusion injury via atte-nuating oxygen free radical and increasing the expression of iNOS mRNA and NO production.
【Fund】: 安徽省科技攻关重点资助项目(0613059A);; 安徽医科大学科研基金资助项目(2005Z031)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 6 Hits
1 LI Hong-yue et al (Medical College,Three Gorges University,Yichang,Hubei 443002);Effects of Total Polyphenols Extracted from Toona sinensis Seeds on the Cardiogram and Hemodynamics of Myocardium Ischemia Reperfusion Rats[J];Journal of Anhui Agricultural Sciences;2010-28
2 ZHANG Yun-lan,WANG Wen-yuan(Hunan Yongzhou Vocational Technical College,Hunan Yongzhou 425006,china);Study on Extracting Technology of Total Flavones from Rhododendron by Orthogonal Design[J];Guangzhou Chemical Industry;2009-03
3 LE Zhiyong,QIN Xiaoling,FANG Nianbai,YU Shanggong(Key Laboratory of Resource and Complex Prexcription of TCM,Hubei University of Chinese Medicine,Wuhan 430065);Effects of Rhizoma Alismatis Decoction on Homodynamics in Rats with Myocardial Ischemia Reperfusion Injury[J];Journal of Hubei University of Chinese Medicine;2012-05
4 SONG Xiao-kun,CAI Jiu-Ying,ZONG Tong-yan,et al(Department of Cardiology,the First Affiliated Hospital of Liaoning Medical University, Jinzhou,Liaoning 121001,P.R.China);Protective effect of different dose of Catalpol Preconditioning on ischemiareperfusion injured myocardium in rats[J];China Medical Engineering;2011-01
5 ZHANG Mei1,PAN Da-ren2﹡(1.Department of Chemistry and Chemical Engineering,Minjiang University,Fuzhou,Fujian 350108,China; 2.College of Life Science,Fujian Agricultural and Forestry Universities,Fuzhou,Fujian 350002,China);Simultaneous Determination of Four Flavonoids in the Leaves of Rhododendron pulchrum by HPLC[J];Journal of Northwest Forestry University;2013-01
6 SHAO Ying,WU Qi-nan,ZHOU Jing,YUE Wei,CHAO Jian-guo(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,China);Protective effects of total flavones from Lophatherum gracile on myocardial ischemia-reperfusion injury in rats[J];Chinese Pharmacological Bulletin;2013-02
Chinese Journal Full-text Database 3 Hits
1 Cao Wenjun, Chen Ruifen, Liu Guozhen Department of Pathology, Capital University of Medical Sciences;Protecting Effects of Quercetin on Myocardium Ischemia Repurfusion Injury in Rats[J];Journal of Capital University of Medical Sciences;2004-03
2 WANG Wei-Qun;ZHANG Yan;FANG Zhi-Lian; et al(Dept. of Pharmacology, Anhui Medical University, Hejei 230032);Effect of hyperin on myocardial lipid peroxidation[J];CHINESE PHARMACOLOGICAL BULLETIN;1995-02
3 Fan Yifei, Kong Dehu, Chen Zhiwu, et al (Dept of Pharmacology, Anhui Medical University, Hefei 230032);Effect of total flavones of rhododendra on myocardial ischemic and reperfusion injury[J];Acta Universitatis Medicinalis Anhui;2006-02
Chinese Journal Full-text Database 10 Hits
1 Qiu Jiongliang, Chang Yan, Zhu Xinqiang Department of Toxicology, Zhejiang University, Hangzhou\ 310006;USE IN VIVO MULTIPLE ENDPOINTS ASSAY FOR STUDYING ESTROGENICITY OF ENDOSULFAN[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-05
2 SHAN Bao-en 1 ,GUO Lan-tao 1 ,DONG Qing 1 ,MA Hong 2 (1.Research Center,The Fourth Hospital of Hebei Medical University,Shijiazhuang,050011,Hebei,China; 2.MD Technologies,Inc.845Pheasant Woods Drive Manchester,Mo63021,USA);Syk Can Influence As_2O_3 Induc ed Brain Tumor Cell Cycle Defects[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-06
3 SHAN Bao-en1,LIU Dong-qing2,LIANG Wen-jie1,ZHANG Jing1,LI Qiao-xia1(1.Research Center of the Fourth Hospital of Hebei Medical University,Shijiazhuang,050011,China;2.The First Hospital of Handan);The Anti-tumor Effect and Immunoregulatory Activity of PE2 From Rhizoma Menipermi Extracts in Vivo[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-05
4 SHEN Ye-shou,ZHENG Li-jun,WANG Zheng-liang,GU Li-ping(Laboratory of Glycoconjugate and Glycotechnology, Institute of Biochemistry and Microbiology, Anhui University, Hefei 230039,Anhui, China);Experimental Study on Anti-tumor Effects of Intracellular Polysaccharide from Phellinus Linteus[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-04
5 Li Guoxian;Analgesic and Central Inhibitory Action of the Essential of Aristolochia Mollisima[J];Journal of Anhui University(Natural Sciences);1989-01
6 CHEN Qin~1, TAO Xia-ping~2 (1.School of Life Science, Anhui University, Hefei230039,China; 2. China Academy of Traditional Chinese Medicine, Beijing100700, China);Experimental study of baochunjing capsules on effect of nourishing kidney and tonic yang[J];Journal of Anhui University(Natural Sciences);2004-03
7 DENG Xu et al (The National Base of Life Science and Biotechnology Education,Northwest A & F University,Yangling,Shaanxi 712100);Preliminary Study on Antimicrobial Activity of Fermentation Broths of Oudemansiella mucida[J];Journal of Anhui Agricultural Sciences;2006-19
8 ZHANG Gui-zhi et al(Animal Science Department,Zhengzhou College of Animal Husbandry & Engineering,Zhengzhou,Henan 450011);Joint Antibacterial Action between TMP and SMM in Vitro[J];Journal of Anhui Agricultural Sciences;2007-36
9 CAI Zhi-hua(Institute of Bio-pharmacies,College of Life Science,Chongqing Normal University,Chongqing 400047);Primary Exploration on the Extraction Technology of Crude Superoxide Dismutase from Chinese Quince[J];Journal of Anhui Agricultural Sciences;2008-05
10 CHEN Jiong-ran et al(Lanzhou Institute of Animal Husbandry and Veterinary,Chinese Academy of Agricultural Sciences,Lanzhou,Gansu 730050);Research on the Effect of the Compound Oral Chinese Medicine on Anti-inflammatory of Mice[J];Journal of Anhui Agricultural Sciences;2010-26
China Proceedings of conference Full-text Database 10 Hits
1 HU Xiao-bo,LIU Yang,ZHANG Xue-nong 1 (Department of Pharmaceutics,School of Pharmaceutical Science,Suzhou University;Jiangsu Suzhou 215123);Study on the anti-tumor activities of pH-sensitive Osthol-Nanoparticles[A];[C];2011
2 WANG Guo-dong WANG Zhu HAN Jun-hua HE Mei Institute of Nutrition and Food Safety,Chinese Center for Disease Control and Prevention,Beijing 100050,China;STUDY OF THE MODULATING EFFECTS OF PHYTOSTEROL ON SERUM LIPID[A];[C];2007
3 ;Study on the Functional Effect of Chufa Functional Component[A];[C];2004
4 Pan Hua-Xin, Wang Pei-Xxun, Zhou Lian, Cao Liu-Ying, Liang Rui-Yan (Immunological Laboratory of Clinical Pharmacology Institute, Guangzhou University of TCM. Guangzhou 510405. China);Comparison of anti-inflammatory and immunosuppress effects of two kind of tablets of tripterygium wilfordii polyglycosidium[A];[C];2006
5 WANG Xiao HU Shixing LIN Shaochun GUO Xuejun ZOU Yihai (Zhongshan Ophthalmic Center, Zhongshan University, Guangzhou, 510060; The Ophthalmology hospital, China Academy of TCM, Bejing, 100040 3 LAC, Guangzhou University of TCM, Guangzhou, 510405);Effects of the Lighting Decoction in models of Acute Light Damage in Rat's Retina[A];[C];2006
6 Zhang Dawei Bing Guoqiang LiPing Yang Donghua Yu Yanbo Liu Zhanjun Guo Chao Xu Caiyun (Center of Laboratory Animal, School of Basic Medical Sciences, Jilin University, Changchun, Jilin, 130021; Laboratory Center, College of Physical Education, Jilin University, Changchun, Jilin, 130012; Observation Room of Laboratory Animal, No. 2 School of Clinical Medicine, Jilin University; Laboratory Animal Room, Changchun Biological Products Research Institute; Changchun Jingyou Medicine Joint-stock Limited Company);Experimental animal barrier environment commonly used disinfection drugs stimulant quality and toxic experiment (五) --Inspiration toxicity experiment of 2% content peracetic Acid solution[A];[C];2006
7 HONG Hua~1,ZHAO Xiang-ren~2,LIU Huai-yu~1 (1.Laboratory Animal Center of Jilin University,Changchun,Jilin,130021 2.Dentrial Medical Colege of Jilin University,Changchun,Jilin,130041 );Safety Reevaluation of Tiopronin Injection[A];[C];2010
8 Suofei -ya Huang peiyou li qiang Wu liya. yiming ( College of Life science and techonolgy, Xinjing University, Wurumuqi, xinjing830046 College of Pharmacy, Xinjiang Medical University, Wurumuqi, Xinjiang 830011);The actue virulence of Cumin Seed Oil and protective effects on the experimental gastric ulcer[A];[C];2005
9 Chen Yan,Wu Li-ya,Chen Rong(Traditional Chinese physician hospital of Xinjiang autonomous region,Urumqi 830054,china);Experimental Study on Protective Effect of Celery root Against Acute Liver Injury[A];[C];2008
10 Yan Zen-kai1, Zhu Hui-ling2, Hu Chun-ju3, Huang Xian-ju2 (1. Department of Chemistry, Hanshan Normal University, Chaozhou 521041; 2. Medical School of Yangtze University, Jingzhou 434000; 3. Department of medical, Hanshan Normal University, Chaozhou 521041);Isolation and Pharmacological Action of Dihydromyricetin[A];[C];2006
Chinese Journal Full-text Database 10 Hits
1 HU Shang-lian et al (College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan 621002);Effects of GA_3 and IAA on the Dynamic Accumulation of Flavonoid Content in Neosinocalamus affinins[J];Journal of Anhui Agricultural Sciences;2008-08
2 WANG Xiao-hua et al(Department of Chemistry and Life Science,Xiangnan University,Chenzhou,Hunan 423000);Study on Extracting Total Flavonoids from Hypericum perfortum L. with Microwave-assisted Extraction[J];Journal of Anhui Agricultural Sciences;2009-14
3 XU Xiao-mei et al (Ministry of Agriculture Key Laboratory of Rubber Biology/State Key Laboratory Incubation Base for Cultivation and Physiology of Tropical Crops Rubber Research Institute,Chinese Academy of Tropical Agricultural Sciences,Danzhou,Hainan 571737);Advances in the Studies of Phenylalanine Ammonialyase[J];Journal of Anhui Agricultural Sciences;2009-31
4 ZHANG Mei et al(College of Life Science,Fujian Agriculture and Forestry Universities,Fuzhou 350002);Analysis of the Flavonoids in the Leaves of Rhododendron Pulchrum Sweet by HPLC-MS[J];Journal of Anhui Agricultural Sciences;2012-09
5 ZOU Hao- jun,MING Liang;Progress of studies on anti-inflammation, immunodulatory and anti-senility effects of total flavones[J];Journal of Anhui Health Vocational & Technical College;2003-06
6 JIANG Qin~(1),DONG Liu-yi~(1),FANG Ming~(1),LI Jing-pei~(2),CHEN Zhi-wu~(1),MA Chuan-geng~(1)(1.Dept of Pharmacology;2.Dept of Microbiology and Parasitology,Anhui Medical University,Hefei 230032);Antiviral action of total flavone of abelmoschus manihot L medic in vitro[J];Anhui Medical and Pharmaceutical Journal;2006-02
7 SHAO Xu1,DONG Liu-yi2,LI Xiao-liang1,GUO Yan2,JIANG Qin2,FANG Ming2(1.Hefei Qixing Medicine and Technology Co.Ltd,Hefei 230088,China;2.Key Laboratory of Antiinflammatory andImmunopharmacology,Ministry of Education,Key Laboratory of Chinese Medicine Research and Development,State Administration of Traditional Chinese Medicine,Department of Pharmacology,Anhui Medical University,Hefei 230032,China);Effects of vitexin on hemodynamics and myocardial oxygen consumption in anesthetized dogs[J];Anhui Medical and Pharmaceutical Journal;2010-09
8 TIAN Xiao-yan1,LIU Yan-ji2(1.Liaoning University of Petroleum and Chemical Technology,Fushun,Liaoning 113001,China;2.Biotechnology College,Shenyang Agriculture University,Shenyang,Liaoning 110161;China);The Effect of ABA on Cyanidin Content and Partial Synthetic Key Enzymes of Nanguo Pear[J];Northern Horticulture;2008-12
9 YANG Hai-yan;SONG Xian-liang.College of Materials Science and Technology,Key Laboratory of Beijing for Wood Science and Engineering,Key Laboratory of Wood Materials Science & Application of Ministry of Education,Beijing Forestry University,100083,P.R.China.;Separation and structure identification of flavonoids from Melia toosendan Sieb.et Zucc.[J];Journal of Beijing Forestry University;2009-S1
10 WU Guo-Juan, ZHANG Zhong-Wen et al (Beijing Agricultural College,Beijing 102206);Antibacterial Effects of ChineseHerbal Medicines on Six Pathogenic Bacteriafrom Dairy Cows Mastitis[J];Journal of Beijing Agricultural College;2003-03
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 LIANG Kai,KONG Xiao-long,QIN Zhen-ming,MO Feng-zhen,WANG Yong-ling,HUANG Shao-de,GUO Mei-hong(Department of Pharmacology,Pharmaceutical College,Guangxi Medical University,Nanning 530021,China);Protective Effects of Hyperin on the Hydrogen Peroxide-Injured Myocardial Cells[J];Guangxi Medical Journal;2012-12
2 HUANG Ke-xin;SHI Bo;YE Bao-guo;SONG Xue-song;Morphology Center,Norman Bethune College of Medicine,Jilin University;Department of Anesthesiology,First Hospital,Jilin University;;Effects of atorvastatin on myocardial enzymes and apoptosis in rat with myocardial ischemia-reperfusion injury and mechanism of its protection on myocardium[J];Journal of Jilin University(Medicine Edition);2013-05
3 DAI Xiong;YAN Jie-kuan;GAN Xiu-hai;School of Chemistry and Life Science,Guizhou Normal College;;Research development of flavnoids[J];Journal of Guizhou Normal College;2013-09
4 ZHANG Xiujie1,YIN Anchun1,LIU Jing2(1.Department of Nursing,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning,China; 2.Regenerative Medicine Centre,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning,China);Neuroprotective Effect and Treatment Prospect of Catalpol in Rehmannia[J];Liaoning Journal of Traditional Chinese Medicine;2013-06
5 CHEN Lin College of Chemistry & Chemical Engineering,China West Normal University,Nanchong 637002,China;Bioactivities of Extracts from Toona sinensis against Sitophilus zeamais[J];植物病虫害研究(英文版);2010-05
6 Zhou Fangjie,Chen Zhiwu(Dept of Pharmacology,Anhui Medical University,Hefei 230032);Hydrogen sulfide induced the endothelium-derived hyperpolarizing factor dilation in rat middle cerebral artery[J];Acta Universitatis Medicinalis Anhui;2011-08
7 CAI Sheng-nian,FAN Yi-fei,CHEN Zhi-wu Department of Pharmacology,Anhui Medical University,Hefei 230032,Anhui,China;Hyperpolarization of hydrogen sulfide on the membrane potential of vascular smooth muscle cell in rat middle cerebral artery[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2011-02
8 YU Jin,CUI Bai-ji,ZHANG Xiu-rong,PENG Xiu-ling,LI Jing,PENG Liang (School of Pharmacy,Jilin Medical College,Jilin 132013,China);Optimization of Extraction Process for the Alcohol-soluble Effective Components from Schisandra chiesis(Turcz.) Baill. by Orthogonal Design[J];Herald of Medicine;2010-09
9 HAN Li-li,FAN Yi-fei,CHEN Zhi-wu Department of Pharmacology,College of Basic Medicine,Anhui Medical University,Hefei 230032,China;Inducing effect of total flavones in rhododendra on endothelium-derived hyperpolarizing factor responses in cerebral basilar artery of rats subjected to global cerebral ischemia reperfusion[J];Chinese Traditional and Herbal Drugs;2011-06
10 Sun Xuanjun,Hu Youyang,Chen Zhiwu(Dept of Pharmacology,Anhui Medical University,Hefei 230032);The effects of CSEsiRNA on the expression of CSE and H_2S in EAhy926 cells[J];Acta Universitatis Medicinalis Anhui;2012-08
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Cai Qing, Rong Yezhi, Huang Koufang et al ( Research Lab. for Myocardial Disease, Shanghi Second Medical University, Shanghai 200092 );EFFECT OF ADRIAMYCIN ON LEAKAGE OF LACTATE DEHYDROSENASE(LDH) & CONTENT OF MALONDIALDEHYDE (MDA) IN CULTURED MYOCARDIAL CELLS[J];Chinese Pharmacological Bulletin;1990-04
2 ZWChen,CGMa,MFangandSYXu (Department of Pharmacology, Anhui Medical University,Hefei230 0 3 2);THEBLOCKINGEFFECTOFHYPEKINON THE INWARD FLOWOFCALCIUMION[J];ACTA PHARMACEUTICA SINICA;1994-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved