Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Traditional and Herbal Drugs》 2009-01
Add to Favorite Get Latest Update

Toxicity of Radix Aconitii on Focal adhesion signal pathway of mice

ZHANG Zhong-lin1,2,PENG Cheng1,LIU Hong-wei3(1.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;2.Chengdu Medical College,Chengdu 610083,China;3.Shanghai Biochip Co.,Ltd.,Shanghai 201203,China)  
Objective To study the toxicity and its mechanism of Radix Aconitii from genetic and molecular levels.Methods According to the requirements of ICH,the acute toxicity experiment was carried out under the condition of SPF by ig administration of the decoction of Radix Aconitii to mice.Gene expression profiling was used to describe whole-genome of five organs in mice,the related data were analyzed by using bioinformatics statistics,such as Cluster,GO,and Pathway,and the results were validated through quantitative PCR.Results The effects of Radix Aconitii on the key genes of the Focal adhesion pathway of mice,such as ECM,FAK,Cdc42,were remarkably.Conclusion The reason why Radix Aconitii produces the toxicity is probably that Radix Aconiti could cause the toxicity of Focal adhesion signal pathway through influencing the key genes.
【Fund】: 国家自然科学基金重点项目(30230410)
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Cui-li;LI Kun;FU Li-na;YANG Xiao-yun;PANG Rong;XIN Jian-hao;School of Medicine,Huanghe S & T College;;Current Status of the Relationship Between the Storage and the Active Components of Traditional Chinese Medicine[J];广州化工;2015-20
2 BIAN Yu-hong1,ZHUANG Peng-wei1,WANG Li2,ZHOU Hui-fang1,ZHANG Yan-jun1 1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2.Tianjin Hospital of Infectious Diseases,Tianjin 300192,China;Research progress on discovery of drug potential toxicity and perspective on safety evaluation of Chinese materia medica[J];中草药;2011-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 KONG Qing-xi,YAO Quan-sheng, HUANG Yi-yi,LI Rong-rong,LI Man,LV Juan,YANG Ran Tripod Preclinical Research Laboratories, Nanjing 211800, China;Request for peer review on toxicological pathology[J];药物评价研究;2011-05
2 WU Yuan-feng, LUAN Yang, QI Xin-ming, REN Jin Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;Advance in study on early and rapid assays of genotoxicity[J];药物评价研究;2011-04
3 LI Hua1,2,TANG Na-ping2,MA Jing2,CHEN Chang-xun1(1.School of Chinese Herb,Shanghai University of Traditional Chinese Medicine,Shanghai 201203; 2.National Shanghai Center for New Drug Safety Evaluation & Research,Shanghai 201203,China);Study on the cardiotoxicity of Tripterygium wilfordii glycosides in Beagle dogs[J];世界临床药物;2011-04
4 Wang Yuguang~1,Ma Zengchun~1,Liang Qiande~1,Liu Ming~1,Lu Beibei~1,Tan Hongling~1, Xiao Chengrong~1,Gao Yue~1,Zhang Boli~2 (1.Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China; 2.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China);Study on the Eighteen Incompatible Pairs Based on Cytochrome P450[J];世界科学技术(中医药现代化);2011-01
5 ZHOU Hui-fang,WANG Li,ZHANG Yan-jun,BIAN Yu-hong(College of Chinese Pharmacology,Tianjin University of Tranditional Chinese Medicine,Tianjin 300193,China);The progress in application of embryonic stem cell-based metabonomics in toxicology research[J];中国药理学通报;2011-02
6 MENG Fan-cui1,XU Wei-ren1,ZHANG Zong-peng2,3,TANG Li-da2 1.Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China;2.Tianjin State Key Laboratory of Pharmacokinetics and Pharmacodynamics,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China;3.Drug Evaluation Center,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China;Drug toxicity upon important organs and prediction in early development[J];药物评价研究;2011-01
7 Gui Chun,Chen Menghua,Lin Song,Wei Yongxian(Department of Cardiology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021);Cytotoxicity effects of shikonin on rat cardiomyocytes in vitro[J];中药药理与临床;2010-06
8 LIANG Qi1,NI Cheng1,YAN Xianzhong2,XIE Ming1,ZHANG Yanxia1,ZHANG Qi2,YANG Meijuan1,PENG Shuangqing2,ZHANG Yuzhong 1(1.Department of Formulaology,Beijing University of Chinese Medicine,Beijing 100029,China;2.National Center of Biomedical Analysis,Beijing 100850,China);Comparative study on metabonomics and on liver and kidney toxicity of Aristolochia fangchi and Stephania tetrandra[J];中国中药杂志;2010-21
9 HE Yong-ming1 ZHONG Qin-qing1,2 WANG Kai1WANG Min-ru1 YANG Hong1 LIN Ju-chun21.Department of Veterinary,Foshan University,Foshan 528000,China;2.College of Veterinary Medicine,Sichuan Agricultural University,Ya'an 625014,China;Cardiotoxicity of Ephedra to Rabbit Model System[J];华中农业大学学报;2010-04
10 ZHANG Zhi-hua1,2,WU Hong-hai2,XUE Gai2,GUO Ding-ni2,HOU Yan-ning1,2 (1.Hebei Medical University,Hebei Shijiazhuang 050017,China;2.Dept.of Pharmacology,Bethune International Peace Hospital,Hebei Shijiazhuang 050082,China);Cellular toxicity of isoniazid used together with rifampicin and the metabolites of isoniazid on QSG-7701 hepatocytes[J];中国医院药学杂志;2010-08
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 Liu Yahui;Chen Yuwen;School of Business Administration,Shenyang Pharmaceutical University;;The Risk Research of Cytotoxicity Screening in Research and Development of New Drugs[J];中国药业;2015-17
2 HUANG Qun;YANG Gaihong;YUAN Jinbin;YANG Wuliang;CHEN Haifang;YAN Zhihong;Ministry of Education Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Jiangxi University of Traditional Chinese Medicine;;Application of Metabonomics in Toxicology Research of Traditional Chinese Medicine[J];中药新药与临床药理;2014-03
3 ZOU Yu,LIU Yu-zhang,ZHANG Chun,FAN Li,ZHOU Li,NIU Ying-cai (Institute of Medicine,Qiqihaer Medical College,Qiqihaer 161006,China);Ability of Learning and Memory of Offspring Affected by Exposure of Normal and Blood-stasis Pregnant Rats to Curcumae Rhizoma[J];中国实验方剂学杂志;2013-12
4 WANG Yu-guang,MA Zeng-chun,LIANG Qian-de,TANG Xiang-lin,GAO Yue Department of Pharmacology and Toxicology,Institute of Radiation and Irradiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China;Thoughts and methods for toxicity study on Chinese materia medica[J];中草药;2012-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved