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《Chinese Traditional and Herbal Drugs》 2009-01
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Toxicity of Radix Aconitii on Focal adhesion signal pathway of mice

ZHANG Zhong-lin1,2,PENG Cheng1,LIU Hong-wei3(1.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;2.Chengdu Medical College,Chengdu 610083,China;3.Shanghai Biochip Co.,Ltd.,Shanghai 201203,China)  
Objective To study the toxicity and its mechanism of Radix Aconitii from genetic and molecular levels.Methods According to the requirements of ICH,the acute toxicity experiment was carried out under the condition of SPF by ig administration of the decoction of Radix Aconitii to mice.Gene expression profiling was used to describe whole-genome of five organs in mice,the related data were analyzed by using bioinformatics statistics,such as Cluster,GO,and Pathway,and the results were validated through quantitative PCR.Results The effects of Radix Aconitii on the key genes of the Focal adhesion pathway of mice,such as ECM,FAK,Cdc42,were remarkably.Conclusion The reason why Radix Aconitii produces the toxicity is probably that Radix Aconiti could cause the toxicity of Focal adhesion signal pathway through influencing the key genes.
【Fund】: 国家自然科学基金重点项目(30230410)
【CateGory Index】: R285.5
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