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《Chinese Traditional and Herbal Drugs》 2012-01
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Anti-hepatitis virus constituents from Corydalis saxicola

WU Ying-rui1,MA Yun-bao2,ZHAO You-xing2,YAO Shu-ying2,ZHOU Jun2,GONG Qing-fang1,CHEN Ji-jun2 1.Guangxi Institue of Boatny,Chinese Academy of Sciences,Guilin 541006,China 2.Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China  
Objective To study the anti-HBV constituents from Corydalis saxicola.Methods The constituents were repeatedly purified by column chromatography and were identified on the basis of spectral analysis and comparison of their spectral data with those previously reported.Compounds isolated in large amounts were assayed against HBV.Results Sixteen compounds were identified to be dihydrosanguinarine(1),d-corydaline(2),cavidine(3),stylopine(4),6-acetonyl-5,6-dihydrosanguinarine(5),dihydrochelerythrine(6),tetrahydropalmatine(7),adlumidine(8),()-salutaridine(9),palmatine(10),protopine(11),berberine(12),coptisine(13),thalifaurine(14),dehydroapocavidine(15),and(+)-magnoflorine(16).Compounds 5,6,8—11,13,and 16 with high amounts were chosen to detect anti-HBV activities.Compounds 5 and 8 were moderately active,compounds 11 and 16 showed weak inhibitory effects,while compound 6 exihibited the most potent activity against HBsAg and HBeAg secretions in HepG 2.2.15 cell line,followed by compound 9.Conclusion Compounds 1,4—6,8,9,13,14,and 16 are isolated from C.saxicola for the first time.Compound 10 is the main constituent and compound 6 exihibits the most potent activity against HBV.
【Fund】: 广西自然科学基金资助项目(桂科基0832021)
【CateGory Index】: R284.1
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