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《Chinese Traditional and Herbal Drugs》 2012-01
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Establishment of "combinatorial screening" library of efficacy substances for Qingluo Tongbi Decoction

ZHANG Xin-long1,GUO Li-wei1,ZHOU Xue-ping2,CAO Yun-tai1,SHI Dong-lei1,PAN Lin-mei1,ZHU Hua-xu1 1.Key Laboratory of Separation Engineering for Chinese Medicine Compound,Nanjing University of Chinese Medicine,Nanjing 210029,China 2.The First Affiliated Hospital,Nanjing University of Chinese Medicine,Nanjing 210029,China  
Objective Attempting to create a "chemical diversity" combinatorial library consisting of active components of Chinese materia medica compounds.Methods This paper was based on the theory of "thinking and method of ‘combinatorial screening’ of Chinese material medica compound",using the Qingluo Tongbi Decoction(QTD) which has exact effect against rheumatoid arthritis as system.Re-combination group of the formulation was used and various industrial separation techniques,such as resin and membrane,were used to replace the diversity of combinatorial chemistry synthetic route.Different products were used to establish combinatorial library using "Building Block".Results Different contents of active components in each "Building Block" were found during the establishment of combinatorial libraries.AB-8 resin had good adsorption and desorption functions on sinomenine,and good refined effects on saponin as well.The contents of kirenol were different in each "Building Block" of different combinations.Each "Building Block" had a relative high content of total flavonoids.Conclusion Different combinations and separation techniques lead the differences in types and contents of chemical constituents.So certain pharmacodynamic experiments are needed to evaluate the preparation and to filter out the relevant active "Building Blocks".
【Fund】: 国家自然科学基金资助项目(81072749);; 国家教育部高校博士点基金项目(20103237110004)
【CateGory Index】: R284.2
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