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《Chinese Traditional and Herbal Drugs》 2012-01
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Preparation and process optimization of gambogenic acid inclusion complex of freeze-dried powder injection

HU Hai-xia,WANG Xiao-shan,PENG Dai-yin,LI Qing-lin Key Laboratory of Xin’an Medicine,Ministry of Education,Anhui Province Key Laboratory of Modern Chinese Medicine,College of Pharmaceutics,Anhui University of Traditional Chinese Medicine,Hefei 230031,China  
Objective To optimize the preparation of gambogenic acid hydroxypropyl-β-cyclodextrin(HP-β-CD) inclusion complex of freeze-dried powder injection.Methods Gambogenic acid HP-β-CD inclusion complex of freeze-dried powder injection was prepared by freeze-drying method,gambogenic acid content was determined by HPLC,and the preparation was optimized by orthogonal design taking inclusion rate as index.Results The optimized preparation process for inclusion was that the reaction mass charge ratio(HP-β-CD-gambogenic acid) was 10∶1,for 5 h at 20 ℃.The inclusion rate of prepared inclusion complex was higher;The freeze-dried powder was with color uniformity,fluffy texture,and good solubility.Conclusion The process is reasonable and with good reproducibility.
【Fund】: 国家重大新药创制专项(2009ZX09103-399);; 安徽中医学院青年科学研究基金(2010qn005)
【CateGory Index】: TQ461
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5 LI Xiang,HU Hai-xia,ZHOU An,et al(The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei Anhui 230031,China);Isolation and purification of Gambogenic acid by preparative HPLC[J];安徽医药;2012-10
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