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《Chinese Traditional and Herbal Drugs》 2012-01
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Preparation and process optimization of gambogenic acid inclusion complex of freeze-dried powder injection

HU Hai-xia,WANG Xiao-shan,PENG Dai-yin,LI Qing-lin Key Laboratory of Xin’an Medicine,Ministry of Education,Anhui Province Key Laboratory of Modern Chinese Medicine,College of Pharmaceutics,Anhui University of Traditional Chinese Medicine,Hefei 230031,China  
Objective To optimize the preparation of gambogenic acid hydroxypropyl-β-cyclodextrin(HP-β-CD) inclusion complex of freeze-dried powder injection.Methods Gambogenic acid HP-β-CD inclusion complex of freeze-dried powder injection was prepared by freeze-drying method,gambogenic acid content was determined by HPLC,and the preparation was optimized by orthogonal design taking inclusion rate as index.Results The optimized preparation process for inclusion was that the reaction mass charge ratio(HP-β-CD-gambogenic acid) was 10∶1,for 5 h at 20 ℃.The inclusion rate of prepared inclusion complex was higher;The freeze-dried powder was with color uniformity,fluffy texture,and good solubility.Conclusion The process is reasonable and with good reproducibility.
【Fund】: 国家重大新药创制专项(2009ZX09103-399);; 安徽中医学院青年科学研究基金(2010qn005)
【CateGory Index】: TQ461
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【References】
Chinese Journal Full-text Database 5 Hits
1 HU Hai-xia;WANG Xiao-shan;Pharmaceutical Department of Anhui University of Traditional Chinese Medicine;;Pharmacokinetics of gambogenic acid inclusion complex in rats[J];中成药;2014-03
2 WANG Xun-cui;ZHU Guo-qi;CHENG Hui;LI Qing-lin;Key laboratory of Xin'an Medicine,Ministry of Education/Experimental Center for Scientific Research,Anhui University of Chinese Medicine;;Gambogenic Acid Induces Mitochondria-dependent Apoptosis in Human Gastric Carcinoma Cell Line[J];中药材;2014-01
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【Citations】
Chinese Journal Full-text Database 4 Hits
1 ZHU Guo-qi,CHENG Hui,WANG Xun-cui,WANG Xiao-shan,LI Qing-lin(Experimental Center for Scientific Research,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Inhibitive Effects of Gambogenic Acid on Proliferation of Lung Adenocarcinoma A549 Cells In Vitro[J];安徽中医学院学报;2011-01
2 XIE Peng,LIANG Shu-wa,MING Fei-ping,LAN Bi-feng,LI Mei(Guangzhou Microbiology Recearch Institute,Guangzhou,Guangdong 510250,China);Study on Freeze-drying Process of Asparaginase for Injection[J];今日药学;2010-11
3 LIU Yan1,CHENG Xiao-xiang2,GUO Chuan-min2,CHAI Zhen-hai1,ZHANG Zong-peng1(1.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China;2.Tianjin Center for Drug Safety Evaluation and Research,Tianjin 300193,China);Comparative study on toxicity of intravenous and intraperitoneal injection of Hydroxypropyl-β-cyclodextion in rats[J];现代药物与临床;2009-06
4 CHENG Hui,PENG Dai-yin,WANG Xiao-shan,TANG Li-jian,HUANG Peng,LI Qing-lin(Anhui Key Laboratory of Modern Chinese Materia Medica,Anhui College of Traditional Chinese Medicine,Hefei 230038,China);Antitumor effects of neogambogic acid both in vivo and in vitro[J];中草药;2008-02
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