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《Chinese Traditional and Herbal Drugs》 2012-01
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Toxicity-attenuating effect of processed rhubarb products based on bio-heat activity in Tetrahymena thermophila BF5

LI Hui-fang1,MA Yong-gang2,XIAO Xiao-he2,LIU Yi3 1.Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China 2.China Military Institute of Chinese Materia Medica,302 Military Hospital,Beijing 100039,China 3.College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China  
Objective To explore the toxicity difference of various processed rhubarb products on Tetrahymena thermophila BF5.Methods The effects of various processed-rhubarb products on parameter of bio-heat activity in T.thermophila BF5 were invastigated by a TAM air isothermal microcalorimeter.Results Various processed rhubarb products had different inhibition on the growth of T.thermophila BF5 in different degrees.The order of intensity was crude rhubarb alcohol-processed rhubarb steamed rhubarb carbonized rhubarb.The inhibition on the growth of T.thermophila BF5 was with the phenomenon of tGbeing increased,Pmax being lowered down,and tmaxbeing delayed.The heat production during the growth of T.thermophila BF5s was reduced in varying degrees,and the reducing of crude rhubarb was the most obvious.Conclusion It could be concluded that the processed rhubarb could attenuate the toxicity significantly.The study on the bio-heat activity of T.thermophila BF5 is suitable for the early screening on toxicity of Chinese materia medica.
【Fund】: 国家科技部“十一五”科技支撑计划(2006BAI08B03)
【CateGory Index】: R285
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【Citations】
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