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《Chinese Traditional and Herbal Drugs》 2013-01
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Effect of Ginseng Radix and Aconiti Lateralis Radix Praeparata compatibility proportion on dissolution variation of ginsenosides

TANG Xiang-lin1,YI Jian-feng1,2,LIANG Qian-de1,MA Zeng-chun1,WANG Yu-guang1,GAO Yue1 1.Beijing Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850,China 2.Yichun University,Yichun 336000,China  
Objective Ultra performance liquid chromatography coupled with time-of-fight mass spectrometry(UPLC-TOF-MS) was used to reveal the chemical profile of Ginseng Radix and Aconiti Lateralis Radix Praeparata compatibility in different ratios,and to evaluate the content changes of ginsenosides.Methods The analyses were performed on a reversed-phase HSS T3 column(100 mm × 2.1 mm,1.8 μm) using a binary eluent(aqueous 0.1% formic acid,0.1% formic acid-acetonitrile) under gradient conditions.Identifications of ginsenosides were confirmed by comparing MS and retention time with those of the reference compounds and the contents of ginsenosides were represented by the peak area of UPLC-TOF-MS chromatogram.Results After combined with Aconiti Lateralis Radix Praeparata,the contents of the most ginsenosides linearly decreased as the ratio of Ginseng Radix reduced.The dissolution of protopanaxatriol type ginsenoside Re and oleanolic acid ginsenoside Ro was promoted,protopanaxadiol type ginsenosides Rb2,Rb3,Rd and their malonyl derivatives exhibited the suppressed dissolution.Conclusion The dissolution of ginsenosides is diverse after the codecoction with Aconiti Lateralis Radix Praeparata,which may be related to the pharmaceutical effect of the compatibility of Ginseng Radix and Aconiti Lateralis Radix Praeparata.
【Fund】: 国家重点基础研究发展计划(“973”计划 2012CB518402 2011CB505304);; 国家自然科学基金资助项目(81073149);; 北京市自然科学基金资助项目(7112110)
【CateGory Index】: R284.1
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