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《Chinese Traditional and Herbal Drugs》 2013-01
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Study on antitumor inflammatory response of Qinghao-Biejia Formula

QIAN Xiao-dan,WANG Zeng,ZHANG Jia-li,HU Zhi-juan,JIANG Jia-yi,ZHOU Hui-jun College of Pharmaceutical Science,Zhejiang University,Hangzhou 310058,China  
Objective To observe the intervention of antitumor inflammatory response of Qinghao-Biejia Formula,to analyze the dose-effect relationship of the intervention,and to investigate the roles of Qinghao and Qinghao-Biejia combination in the formula.Methods The ICR mice bearing S180 sarcoma were randomly divided into six groups: Qinghao(1.5 g/kg),Qinghao-Biejia combination(1.5 g/kg),Qinghao-Biejia Formula(0.75,1.5,and 3.0 g/kg),and model groups.The drugs were ig administered once daily for 10 d continuously.After the last administration,the tumor weights in mice of each group were detected.The expression of COX-2 and VEGF protein in S180sarcoma was detected by immunohistochemistry and Western blotting methods;Leukocyte numbers were counted by HE staining and optical microscope.Levels of TNF-α,IL-1β,and PGE2 in mice serum were measured by ELISA assay.Results Qinghao-Biejia combination had much stronger antitumor effects and inhibition on PGE2 than single Qinghao.Qinghao-Biejia Formula improved the levels of TNF-α and IL-1β significantly,and also decreased the expression of COX-2 and VEGF protein obviously.No obvious dose-effect relationship was observed in the inhibition on tumor growth by low-,mid-,and high-dose of Qinghao-Biejia Formula.Conclusion Qinghao-Biejia Formula has the inhibition on tumor and interferes the inflammatory response through the regulation of TNF-α and IL-1β.
【Fund】: 浙江省自然科学基金资助项目(Y207432)
【CateGory Index】: R285.5
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1 JIANG Tao1,TANG Chun-ping2,ZENG Zhao-zhi1,ZHANG Jin-hong1,CHEN Yan-fen2(1.Laboratory Animal Center; 2.School of Traditional Chinese Medicine,Guangdong Pharmaceutical College,Guangzhou,Guangdong 510006,China);A study on the antipyretic effects and mechanism of Haojia Xureqing granules[J];Journal of Guangdong Pharmaceutical College;2010-04
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