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《Chinese Traditional and Herbal Drugs》 2013-15
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Chemical constituents of flavonoid glycosides in extract from Ginkgo biloba leaves used for injection

ZHAO Yi-yi,CHEN You-gen,GUO Hong-zhu,FU Xin-tong Beijing Institute for Drug Control,Beijing 100035,China  
Objective To study the chemical constituents of flavonoid glycosides in the extract from Ginkgo biloba leaves used for injection.Methods The constituents of flavonoid glycosides in the 70% ethanol extract from G.biloba leaves were isolated and purified by chromatography over silica gel,MCI,ODS,Sephadex LH-20 columns and RP-HPLC.The structures were identified on the basis of physicochemical properties and spectral data analyses.Results Sixteen compounds were isolated and identified as 5,7dihydroxyl-4′-methoxylflavonol-3-O-rutinoside(1),quercetin-3-O-(2″,6″-α-L-dirhamnopyranosyl)-β-D-glucoside(2),quercetin3-O-[2″-(6′′′-p-coumaroyl)-β-D-glucopyranosyl]-α-L-rhamnopyranosyl-7-O-β-D-glucoside(3),isorhamnetin-3-O-(2″,6″-α-Ldirhamnopyranosyl)-β-D-glucoside(4),rutin(5),luteolin-7-O-β-D-glucoside(6),quercetin-3-O-β-D-glucoside(7),quercetin3-O-(2″-β-D-glucopyranosyl)-α-L-rhamnoside(8),kaempferol-3-O-rutinoside(9),quercetin-3-O-α-L-rhamnoside(10),isorhamnetin-3-O-rutinoside(11),apigenin-7-O-β-D-glucoside(12),syringetin-3-O-rutinoside(13),kaempferol-3-O-(2″β-D-glucopyranosyl)-α-L-rhamnoside(14),quercetin-3-O-α-L-rhamnopyranosyl-2″-(6′′′-p-coumaroyl)-β-D-glucoside(15),and kaempferol-3-O-α-L-rhamnopyranosyl-2″-(6′′′-p-coumaroyl)-β-D-glucoside(16).Conclusion UPLC-PDA shows that all the compounds are flavonoid glycosides in the leaves of G.biloba and are marked in the extract and injection.Compound 1 is isolated from this plant for the first time,named flavonol glycoside K.
【Fund】: 北京市科技计划“研发攻关类”专题(Z07000200540712)
【CateGory Index】: R284.1
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