Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Traditional and Herbal Drugs》 2013-15
Add to Favorite Get Latest Update

Effect of Ampelopsis Radix on dissolution of main chemical constituents in Aconiti Radix Cocta based on RRLC-Q-TOF-MS technology

WANG Hui,CHEN Ning,XU Yan-yan,CHENG Li-li,ZHUANG Peng-wei,LI Yu-bo,ZHANG Yan-jun Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-established State Key Laboratory Cultivation Base,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China  
Objective Under the guidance of eighteen antagonisms of Chinese materia medica,to analyze the effect of Aconiti Radix Cocta combined with Ampelopsis Radix in different ratios on the characteristic constituents and to explore the in vitro compatibility mechanism of Aconiti Radix Cocta and Ampelopsis Radix.Methods A certain weight of Aconiti Radix Cocta was combined with various amounts of Ampelopsis Radix,and a rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry(RRLC-Q-TOF-MS) method based on chemical profiling approach was used to determine the content of alkaloids in decoctions and sediments.The aconitine alkaloids were established and were subjected to PLS-DA and ANOVA to provide intergroup difference and distribution characteristics.In addition,the method of UV spectrophotometer was adopted to determine the content of starch and tannins in Ampelopsis Radix.Results There were certain differences among each group,especially between the single Aconiti Radix Cocta and Aconiti Radix Cocta combined with Ampelopsis Radix at the ratio of 1∶3.With the increasing of the ratio of Ampelopsis Radix in the combination,the content of alkaloids appeared to increase in the decoction while decrease in the sediment.After determination,the mass fractions of starch and tannic acid in Ampelopsis Radix were 25.44% and 0.31%,respectively.Conclusion The aconitine alkaloids could be deposited with the starch in Ampelopsis Radix,meanwhile decreased in the decoction,which establishes the foundation for the further research on the chemical mechanism of Aconiti Radix Cocta combined with Ampelopsis Radix.
【Fund】: 国家重点基础研究发展计划(“973”计划)(2011CB505300 2011CB505302)
【CateGory Index】: R284
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 Liu, Wenlonga,b Song, Fengruia Liu, Zhiqianga Liu, Shuying*,a Zhang, Dafangc (a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) (b Graduate School of the Chinese Academy of Sciences, Beijing 100039) (c College of Pharmacy, Changchun University of Traditional Chinese Medicine, Changchun 130117);Chemical Study on Combination Taboo of Radix aconiti with Rhizoma pinelliae, Fructus trichosanthis, Bulbus fritillariae thunbergli, Radix ampelopsis and Rhizoma bletillae[J];Acta Chimica Sinica;2010-09
2 Zhou,Sisia,b Ma,Zengchun,b Liang,Qiandeb Wang,Yuguangb Tan,Honglingb Xiao,Chengrongb Zhang,Bolic Gao,Yue,b(aAnhui Medical University,Hefei 230032)(bInstitute of Radiation Medicine Sciences,Academy of Military Medical Sciences,Beijing 100850)(cTianjin University of Traditional Chinese Medicine,Tianjin 300193);UPLC/Q-TOF-MS Based Chemical Profiling Approach to Evaluate Chemical Composition of Augmentation Toxicity in Combination of Radix Aconiti and Pinellia Praeparata[J];Acta Chimica Sinica;2012-03
3 Li,Fei a,b Wang,Yuguang,b Yang,Liang b Zhu,Guanxiu a,b Liang,Qiande b Ma,Zengchun b Xiao,Chengrong b Tan,Hongling b Tang,Xianglinb Gao,Yue,b(aXiangya Medical College Central Sourth University,Changsha 570228)(bBeijing Institute of Radiation Medicine,Beijing 100850);Regularity of Toxic Alkaloids during the Combination of Veratrum nigrum and Salvia miltiorrhiza by UPLC-Q-TOF/MS[J];Acta Chimica Sinica;2012-21
4 LI Hong-juan, ZHANG Lei, WANG Shu-guang (Binzhou Medical College, Binzhou 264003, China);Pharmacological Action and Clinical Application of Radix Ampelopsis[J];Food and Drug;2007-10
5 ZHANG Yu - mei ,LU Jing JIANG Yu, YANG Kun, LI Ya - rong, CHENG Xian - long, HE Yi,LIN Rui - chao ( National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050,China; Yongzhou Institute for Drug Control, Yongzhou 425000, China; Huai'an Institute for Drug Control,Huai'an 223200,China;. Jilin Institute for Drug Control,Jilin 132011,China);HPLC Determination of Aconitum Alkaloids and Their Hydrolysis Products in Radix Aconiti and Its Preparata[J];Chinese Journal of Pharmaceutical Analysis;2005-07
6 WANG Yong, SHI Lei, JIN Dong-ming, SONG Feng-rui, LIU Zhi-qiang, LIU Shu-ying (New Drug Laboratory of Changchun Institute of Applied Chemistry, CAS, Changchun 130022, China);Stripping and hydrolyzing balance of aconitic alkaloids in processing of Sini Decoction[J];Chinese Traditional and Herbal Drugs;2003-04
7 PI Zi-feng1,YUE Hao2,SONG Feng-rui1,LIU Zhi-qiang1, LIU Shu-ying1 (1.Changchun Center of Mass Spectrometry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;2.Department of Chemistry,Hong Kong Baptist University,Hong Kong,China);Analysis of aconitine alkaloids in compatible application of Radix Aconiti Lateralis Preparata with different flavour herbs by ESI-MS spectrometry[J];Chinese Traditional and Herbal Drugs;2008-10
8 QI Yao1,2,PI Zi-feng1,SONG Feng-rui1,LIN Na3,LIU Zhi-qiang1 1.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China 2.Graduate School of Chinese Academy of Sciences,Beijing 100039,China 3.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Chemical constituent changes of Aconiti Radix Cocta in compatibility process with Fritillariae Cirrhosae Bulbus and Fritillariae Thunbergii Bulbus[J];Chinese Traditional and Herbal Drugs;2011-12
9 DONG Xin1,2,WANG Shu-min1,ZHU En-zhi1,SONG Feng-rui2,LIU Zhi-qiang2,LIU Shu-ying2 1.Changchun University of Traditional Chinese Medicine,Changchun 130117,China 2.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;Chemical study on compatibility of medicinal plants in Aconitum L. and their processed products with Fritillariae Thunberglii Bulbus and Fritillariae Cirrhosae Bulbus[J];Chinese Traditional and Herbal Drugs;2012-02
10 SU Shu-lan,DUAN Jin-ao~*,LI Wen-lin,TANG Yu-ping,FAN Xin-sheng(Jiangsu Key laboratory for TCM formulae Research,Nanjing University of Chinese Medicine,Nanjing 210046,China);Exploration the Toxicity/Increase Virulence Mechanisms of "Eighteen Incompatible Medicaments" based on Chemical Substances[J];Chinese Journal of Experimental Traditional Medical Formulae;2010-01
Chinese Journal Full-text Database 10 Hits
1 ZHAO Bing et al(Department of Traditional Chinese Medicine,College of Life Sciences,Northwest University,Xi'an,Shaanxi 710069);Pharmacological Progress of Research on Ampelopsis japonica(Thunb.) Makino.[J];Journal of Anhui Agricultural Sciences;2012-09
2 JIANG Jun1,2,JIA Xiao-bin1,FENG Liang1,3,CHEN Yan1,3,YANG Huan1,3,CAI Bao-chang4,WU Hao4,LI Jun-song4(1 Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Nanjing 210028,China;2School of Pharmacy,Jiangsu University,Zhenjiang 212013,China;3Key Laboratory of Scienti c Preparation for Clinical E ective Prescription of State Administration of Traditional Chinese Medicine,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China;4Key Laboratory of Processing of Chinese Materia Medica,Nanjing University of Chinese Medicine,Nanjin 210029,China;);Processing of Chinese medicine:clash-processing and using-corrigent-processing[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-09
3 YANG Ming-hui1,LI Shao-dan1,GAO Yue2 (1Institute of Traditional Chinese Medicine,General Hospital of PLA,Beijing 100853,China;2Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850,China);Exploratory analysis on eighteen incompatible medicaments of Chinese medicinal herbs based on modern clinical application[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-01
4 YANG Ming-hui1,LI Shao-dan1,GAO Yue2(1Institute of TCM,General Hospital of PLA,Beijing 100853,China;2Institute of Radiation Medicine,Academy of Military Medical Science,Beijing 100850,China);Exploratory analysis on eighteen incompatible medicaments of Chinese medicinal herbs based on modern clinical application[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-06
5 TANG Pei-pei,GUO Xiao-fang,BAI Ming,MIAO Ming-san(Henan University of TCM,Zhengzhou 450008,China);Effect of Ampelopsis external application on sores ulcers model[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-03
6 Li Zhiyong1,Tan Peng2,Zhao Hui3,Li Fei2,Sun Jianning2(1 China Minority Traditional Medical Center of Minzu University of China,Beijing 100081 China;2.School of Chinese Pharmacy of Beijing University of Chinese Medicine,Beijing 100102 China;3.School of TCM of Capital Medical University,Bejing 100069,China);Effects of hypaconitine on expression of mRNA of calcium regulated proteins in myocardial cells[J];Chongqing Medicine;2011-25
7 CHEN Xiao-ying1,LIANG Ji-zhi2,LIANG Cong-qing1,HUANG Wen-li1(1.Guangdong College of Pharmacy,Guangzhou,Guangdong 510006,China;2.Guangzhou Hospital of TCM,Guangzhou,Guangdong 510130,China);Determination of hypaconitine in Shuluoling tincture by RP-HPLC[J];Journal of Guangdong College of Pharmacy;2008-02
8 LI Chun-xiao1,ZHANG Ye2,LI Xue-lin1(1The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;2Henan University of Traditional Chinese Medicine,Zhengzhou 450003,China);Exploratory analysis on 'eighteen incompatible medicaments' of Chinese medicinal herbs from rational drug use[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-09
9 GUO Jian-en,FAN Jin-ming,LIU Dan-dan,et al(Chengde Medical College,Hebei Chengde 067000,China);EFFECTS OF RADIX ACONITE COMBINED FRUCTUS TRICHOSANTHISIN ON ACUTE TOXICITY OF MICE[J];Journal of Chengde Medical College;2012-04
10 CHENG Xianyi1,ZHANG Zhiming2,MA Jun1 1 Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;2 University Hospital of Gansu Traditional Chinese Medicine;Research on Incompatiblity and Compatiblity in One of Eighteen Incompatible Medicaments[J];Western Journal of Traditional Chinese Medicine;2013-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LUO Feng-ming,QIU Jin-biao,LI Ming-hua,XIAO Bin-kun (Huizhou Meteorological Station,Huizhou 516001,China);How to do Regression Analysis by Statistical Software SPSS[J];Computer Knowledge and Technology;2008-02
2 LIU Yun-xiang1,LIU Gang2(1.Guangzhou Baiyun Technician Institute,Guangzhou 510450,China;2.College of Mathematics and Computer Science,Hunan Normal University,Changsha 410000,China);Application of Stepwise Regress Analysis in Matlab on Weightiness for Gan-yang-hua-feng Symptoms[J];Computer Knowledge and Technology;2010-34
3 HUANG Wen quan, CHENG Xiang lin, XIAO Hong, XU Zhi hui, SHAO Hua (Department of Chinese and Western Medicine Integration, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Effect of licorice and kansui combination on functions and morphology of rat hearts, livers and kidneys[J];Acta Academiae Medicine Militaris Tertiae;2001-12
4 DAI Fang-guo 1, LUO Ren 1, WANG Yu-guang 2, XIA Cheng-yun 3, TAN Hong-ling 2, XIAO Cheng-rong 2, ZHAO Yong-hong 2, GAO Yue 2 ( 1Department of Traditional Chinese Medicine, The South Medical University, Guangzhou 510515; 2Department of Pharmacological Toxicology, Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850; 3Department of Traditional Chinese Medicine, The Affiliated Hospital of Chuanbei Medical College, Nanchong 637000, China);Compatible effects of euphorbia and glycyrrhiza on CYP2E1 expression and activity in rat liver[J];Acta Academiae Medicinae Militaris Tertiae;2005-08
5 DAI Fang-Guo1,LUO Ren1,WANG Yu-Guang2,XIA Cheng-Yun3,TAN Hong-Ling2,XIAO Cheng-Rong2,ZHAO Yong-Hong2,GAO Yue2 1Department of Traditional Chinese Inter-medicine,School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China,2Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China,3Affialiated Hospital,Chuanbei Medicinal College,Nanchong 637000,China;Effects of Euphorbia coadministration with Glycyrrhiza on CYP3A2 in rat[J];Journal of The Fourth Military Medical University;2005-10
6 Li Li~(1,2), Liu Chunming~2, Wu Wei~1, Yue Hao~1, Liu Zhiqiang~(*1), Liu Shuying~1, Tian Cheng~3~1(Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022)~2(Department of Chemistry, Changchun Teachers College, Changchun 130032)~3(Manzhouli Inspection and Quarantine Technical Centre, Manzhouli 021400);Analysis of Saponins in Extract of Panax Ginseng andPanax Quinquofolium by Liquid Chromatography-Electrospray Ionization Mass Spectrometry[J];Chinese Journal of Analytical Chemistry;2005-08
7 XU Qing-Xuan, WANG Yong, LIU Zhi-Qiang, LIU Shu-Ying*(Laboratory of New Drug Research, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, China)TIAN Cheng(Manzhouli Inspection And Quarantine Technical Centre, Manzhouli 021400, China);Analysis of Norditerpenoid Alkaloids in Roots of Aconitum kusnezoffii by Electrospray Ionization Tandem Mass Spectrometry[J];Chemical Research In Chinese Universities;2005-04
8 Guo Libin, Lu Yan, Chen Shuipin (Guangdong College of Pharmacy,Guangzhou,510224);Study on The Chemical Constituents of Ampelopsis Japonica (Thunb.) Makino[J];ACADEMIC JOURNAL OF GUANGDONG COLLEGE OF PHARMACY;1996-03
9 MA Xue-song,TAN Wei,ZHU Qi-xin(School of Chemical Engineering & Technology,Tianjin University,Tianjin,300072,China);Experimental Study on Filtration Separation technology of the Preparation of extraction Solution of Chinese Traditional Medicine[J];Journal of Filter & Separator;2005-04
10 SU Shu-lan,WANG Tuan-jie,DUAN Jin-ao(1.Jiangsu Key Laboratory for TCM Formulae Research,Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China;2.Pharmacy College,Jiangsu University,Zhenjiang 212013,China);Distribution,chemical components and bioactivity of resin herbs:research advances[J];Journal of International Pharmaceutical Research;2009-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved