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《Chinese Traditional and Herbal Drugs》 2013-15
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Effect of Ampelopsis Radix on dissolution of main chemical constituents in Aconiti Radix Cocta based on RRLC-Q-TOF-MS technology

WANG Hui,CHEN Ning,XU Yan-yan,CHENG Li-li,ZHUANG Peng-wei,LI Yu-bo,ZHANG Yan-jun Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-established State Key Laboratory Cultivation Base,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China  
Objective Under the guidance of eighteen antagonisms of Chinese materia medica,to analyze the effect of Aconiti Radix Cocta combined with Ampelopsis Radix in different ratios on the characteristic constituents and to explore the in vitro compatibility mechanism of Aconiti Radix Cocta and Ampelopsis Radix.Methods A certain weight of Aconiti Radix Cocta was combined with various amounts of Ampelopsis Radix,and a rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry(RRLC-Q-TOF-MS) method based on chemical profiling approach was used to determine the content of alkaloids in decoctions and sediments.The aconitine alkaloids were established and were subjected to PLS-DA and ANOVA to provide intergroup difference and distribution characteristics.In addition,the method of UV spectrophotometer was adopted to determine the content of starch and tannins in Ampelopsis Radix.Results There were certain differences among each group,especially between the single Aconiti Radix Cocta and Aconiti Radix Cocta combined with Ampelopsis Radix at the ratio of 1∶3.With the increasing of the ratio of Ampelopsis Radix in the combination,the content of alkaloids appeared to increase in the decoction while decrease in the sediment.After determination,the mass fractions of starch and tannic acid in Ampelopsis Radix were 25.44% and 0.31%,respectively.Conclusion The aconitine alkaloids could be deposited with the starch in Ampelopsis Radix,meanwhile decreased in the decoction,which establishes the foundation for the further research on the chemical mechanism of Aconiti Radix Cocta combined with Ampelopsis Radix.
【Fund】: 国家重点基础研究发展计划(“973”计划)(2011CB505300 2011CB505302)
【CateGory Index】: R284
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