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《Chinese Traditional and Herbal Drugs》 2013-15
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Preparation and anti-oxidative activity of hydroxytyrosol by alkaline hydrolysis of oleuropein

XIE Pu-jun 1,2,HUANG Li-xin 1,2,ZHANG Cai-hong 1,2,YOU Feng 1,2,ZHANG Yao-lei 1,2 1.Key Laboratory of Biomass Energy and Material,Jiangsu Province,Key and Open Laboratory on Forest Chemical Engineering,SFA,National Engineering Laboratory for Biomass Chemical Utilization,Institute of Chemical Industry of Forest Products,Chinese Academy of Forestry,Nanjing 210042,China 2.Institute of New Technology of Forestry,Chinese Academy of Forestry,Beijing 100091,China  
Objective To prepare hydroxytyrosol(HT) by alkaline hydrolysis of oleuropein and to investigate its anti-oxidative property.Methods According to single factor experiments,four variables: temperature,sodium hydroxide concentration,time,and the ratio of solid to liquid,were selected.On the basis of single factor experiments,orthogonal tests of L9(34) were carried out.HPLC-MS method was also further applied for the qualitative analysis on HT.Under the same conditions,contrast experiments on the acid and alkaline actions were made.Finally,anti-oxidative activity of HT was evaluated.Results The results showed that the selected variables were all highly significant.Also,the descending influence orders on HT were temperature sodium hydroxide concentration time the ratio of solid to liquid.Lastly,the optimal conditions on HT yield were obtained as follow: temperature 90 ℃,sodium hydroxide concentration 0.2 mol/L,time 45min,and the ratio of solid to liquid 1∶15.The HPLC retention time of HT was about 10.3 min,and its relative molecular weight of fragment ion by MS was 134.8.By comparison with the acid action,it was proved that the alkaline action was better in HT yield.In addition,the anti-oxidative activity of HT was carried out on scavenging DPPH radical.The results showed that DPPH scavenging capability of HT was 2.45 times of BHT.Conclusion HT yield is well obtained under the alkaline condition and has a good anti-oxidation.
【Fund】: “十二五”国家科技支撑计划(2012BAD32B10);; “863”课题项目“食品高效节能干燥装备开发与新技术研究”(2011AA100802)
【CateGory Index】: R284.1
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