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《Chinese Traditional and Herbal Drugs》 2013-15
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Optimization of wet ultrafine grinding technology for Hirudo extraction

ZHU Hua-ming 1,FU Ting-ming 1,GUO Li-wei 1,LIU Feng 2,ZHANG Wei 2 1.Key Laboratory of Separation Engineering for Chinese Medicine Compound,Nanjing University of Chinese Medicine,Nanjing 210029,China 2.Shanxi Buchang Pharmaceutical Co.,Ltd.,Xi’an 710075,China  
Objective To study the optimal extraction for Hirudo by wet ultrafine grinding technology.Methods On the basis of single-factor experiments,the response surface analysis was made for exploring the optimal extraction conditions by wet ultrafine grinding technology for Hirudo,with solid-liquid ratio,soaking time,extraction temperature,and grinding time as independent variable and the anticoagulant activity as the response value.According to Box-Behnken principles,the response surface analysis method with four factors and three levels was used.Results The optimum extraction condition for Hirudo by wet ultrafine grinding technology was as follows: solid-liquid ratio 1∶ 12,soaking time 4.9 h,extraction temperature 6.5 ℃,grinding time 12 min;The anticoagulant activity could reach 20.13 U/g.Conclusion The extraction by wet ultrafine grinding technology for Chinese materia medica Hirudo is stable and feasible,and it could be further promoted.
【Fund】: 国家“重大新药创制”科技重大专项(子课题2011ZX09401-308-008);; 国家科技重大专项子课题:中药大品种脑心通胶囊技术改造研究(2011ZX09201-201-26);; 陕西省科技统筹创新工程计划课题(2011KTZB03-01-04)
【CateGory Index】: R284
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