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《Chinese Traditional and Herbal Drugs》 2013-15
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Effects of Tongsaimai Prescription and Tongsaimai Prescription without Achyranthis Bidentatae Radix on ischemic brain injuries in rats

LI Zhuo-qiong,BIAN Hui-min,ZHANG Qi-chun,ZHANG Di-ni,DI Liu-qing,HU Xiao-ying Nanjing University of Chinese Medicine,Nanjing 210046,China  
Objective To investigate the effects of Tongsaimai Prescription(TSMP) and TSMP without Achyranthis Bidentatae Radix(ABR) on ischemic brain injuries in rats.Methods The male SD rats were divided into Sham,model,Nimodipine(32.4 mg/kg),TSMP(crude drug 31.74 g/kg),and TSMP without ABR(crude drug 27.77 g/kg) groups.Except the Sham and model groups,the rats were ig administered once daily,for 3 d.After the treatment,except the Sham group,the cerebral ischemic stroke model was established.After 24 h,the blood and brain tissue were taken,the brain tissue was stained with TTC,and the cerebral infarction ratio was measured.The pathological changes were observed,and the contents of HMGB1,TNF-α,and IL-1β in serum were detected.The expression of NF-κB in ischemia tissue was observed by immunohistochemisty method.Results The expression of HMGB1,TNF-α,and IL-1β increased obviously(P 0.05).TSMP and TSMP without ABR could decrease the contents of HMGB1,TNF-α,and IL-1β,inhibit the expression of NF-κB(P 0.05),and the effect of TSMP without ABR on decreasing IL-1β was stronger.Conclusion Both TSMP and TSMP without ABR could inhibit the activation of HMGB1-related NF-κB signal pathway with the function of anti-imflammation,alleviated encephaledema,and protecting nerve cells.TSMP without ABR has the similar effect on the ischemic brain injuries and the better effect on inhibiting the secretion of inflammatory factor IL-1β.
【Fund】: 国家自然科学基金资助项目(81073071);; 江苏省优势学科建设工程资助项目(2011ZYX3-0021)
【CateGory Index】: R285.5
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