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《Chinese Traditional and Herbal Drugs》 2013-23
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Chemical constituents from fallen leaves of Populus alba × P.berolinensis

WANG Jin-lan;SUN Da-peng;LV Wei-qiang;LI Jun;ZHAO Ming;ZHANG Shu-jun;Institute of Chemistry and Chemistry Engineering,Qiqihar University;  
Objective To study the chemical constituents from the fallen leaves of Populus alba × P.berolinensis and the inhibitory activity of salicin derivatives against SGC-7901 cell.Methods The chemical constituents were isolated and purified on the basis of silica gel column chromatography and HPLC.The structural elucidation was performed according to the physicochemical properties and spectroscopic analysis.The inhibitory activity of salicin derivatives on human gastric carcinoma cells SGC-7901 in vitro proliferation was determined by MTT method.Results Sixteen compounds were isolated and identified as tremuloidin(1),populin(2),chaenomeloidin(3),4′-O-benzoylsalicin(4),salicin(5),tremulacin(6),poliothrysin benzoate(7),catechol(8),benzoic acid(9),tremulacinol(10),6′-O-benzoylsalicin-7-salicylate(11),salicylol(12),salicortin(13),7-O-acetyl-3′-O-benzoylsalicin(14),7-O-acetyl-4′-O-benzoylsalicin(15),and 6′-O-acetyl-2′-O-benzoylsalicin(16),respectively.The inhibitory activity of compounds 7 and 11—13 on the in vitro proliferation of SGC-7901 cell was indicated by MTT and IC50 values were 71.0,122.5,212.7,and 257.8 μmol/L.Conclusion Compounds 4,7,10,11,14—16 are isolated from this plant for the first time.Compound 7 shows the inhibitory activity against SGC-7901 in vitro proliferation.
【CateGory Index】: R284.1
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1 LV Wei-qiang,DING Yu,LIU Ji-mei,WANG Jin-lan,ZHAO Ming,ZHANG Shu-jun* Institute of Chemistry and Chemistry Engineering,Qiqihar University,Qiqihar 161006,China;Study on Chemical Constituents from the Leaves of Populus alba X P.berolinensis[J];Natural Product Research and Development;2013-05
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