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《Chinese Traditional and Herbal Drugs》 2013-23
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Feasibility of replacing cholesterol by β-sitosterol to prepare quercetin liposomes

YU Fan;YANG Jin-ming;College of Pharmacy,Yancheng Teachers University;  
Objective To study the feasibility of preparing quercetin liposomes with β-sitosterol instead of cholesterol and optimize the prescription and preparation of quercetin liposomes.Methods Quercetin liposomes were prepared by film dispersion method with lecithin and β-sitosterol,encapsulation efficiency(EE) was determined by centrifugal precipitation method.EE and drug loading were adopted to evaluate and optimize preparation process as response in orthogonal design.Quercetin liposomes were characterized by particle size,potential,atomic force microscope(AFM) and in vitro release.Results Film dispersion method was the best method to prepare quercetin liposomes with lecithin and β-sitosterol.The optimum preparation process determined by orthogonal design was as follow:the ratio of quercetin to lecithin was 1∶5,the ratio of lecithin to β-sitosterol was 6∶1,pH value of PBS buffer solution was 6.0,the hydration time was 2 h,the EE was(82.55 ± 1.10)%,drug loading was(11.40 ± 1.14)%,particle size was(194.60 ± 4.38) nm,Zeta potential was(-30.45 ± 0.42) mV,and the prepared quercetin liposomes were verified by AFM with round shape and homogenious particle size.There was no difference between new type liposome and ordinary liposome.Conclusion Quercetin liposomes prepared with lecithin and β-sitosterol are practicable.The quercetin liposomes prepared by optimum preparation process have a high EE,good morphology,and reproducibility,and it can be used in industry.
【Fund】: 国家自然科学基金资助项目(81102817);; 江苏省滩涂生物资源与环境保护重点建设实验室项目(JLCBE09021);; 盐城师范学院自然科学基金资助项目(09YCKL010);; 盐城师范学院教研项目(13YCTCJY046);; 盐城师范学院博士科研启动基金资助项目
【CateGory Index】: R94
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