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《Chinese Traditional and Herbal Drugs》 2014-01
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Chemical constituents from root tubers of Rehmannia glutinosa

LIU Yan-fei;LIANG Dong;LUO Huan;HAO Zhi-you;WANG Yan;ZHANG Chun-lei;CHEN Ruo-yun;YU De-quan;State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College;  
Objective To investigate the chemical constituents in the root tubers of Rehmannia glutinosa. Methods The compounds were isolated from the ethanol extract in the root tubers of R. glutinosa by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20 columns, and reversed-phase HPLC. The structures were identified by spectroscopic analysis including MS and NMR data. Results Twenty-nine compounds were isolated and identified as 1, 2, 5, 6-tetrahydro-1-methyl-2-oxo-4-pyridineacetic acid(1), 5-deoxyantirrhinoside(2), 5-deoxylamiol(3), lamiol(4), gardoside(5), genipin-gentiobioside(6), genameside C(7), 6β-hydroxy-2-oxabicyclo [4.3.0] Δ8-9-nonen-1-one(8), jioglutin D(9), jioglutin E(10), martynoside(11), sculponiside(12), 2-phenylethyl-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside(13), acteoside(14), salidroside(15), leucosceptoside A(16), jionoside D(17), deacyl-martynoside(18), jionoside A1(19), jionoside B1(20), 3, 4-dihydroxy-β-phenethyl-O-α-L-rhamnopyranosyl-(1→3)-O-β-D-galacopyranosyl-(1→6)-4-O-caffeoyl-β-D-glucopyranoside(21), 1-(4-methy-2-furanyl)-2-(5-methyl-5-ethenyl-2-tetrahydrofuranyl)-propan-1-one(22), 2-methoxy-4-methylphenyl-O-β-Dapiofuranosyl-(1→6)-β-D-glucopyranoside(23), rhamnopyranosyl vanilloyl(24), syringicacid-4-O-α-L-rhamnopyranoside(25),(7R, 8S, 7′R, 8′S)-4, 9, 4′, 9′-tetrahydroxy-3, 3′-dimethoxy-7, 7′-epoxylignan 9-O-β-D-glucopyranoside(26), 1-methyl-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid(27), tachioside(28), and isotachioside(29). Conclusion Among the isolated 29 compounds, there are 9 iridoid and iridoid glycosides(2—10), 11 phenethylalcohol glycosides(11—21), and 9 other components(1 and 22—29). Compound 1 is a new compound named rehmannidine, and compounds 2—8 and 24—29 are isolated from the plants of Rehmannia Libosch. ex Fisch. et Mey. for the first time. In the preliminary assays, compounds 1, 4, 13, 15, 24, 25, 27, and 28 exhibit the moderate hepatoprotective activites against D-galactosamine-induced HL-7702 cell damage.
【Fund】: 教育部创新团队(IRT1007)
【CateGory Index】: R284.1
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