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《Chinese Traditional and Herbal Drugs》 2014-01
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Effect of Compound Salvia Recipe on cardiac cytochrome P450 in rats

HU Dong-hua;WANG Yu-guang;CHEN Zhi-wu;MA Zeng-chun;LIANG Qian-de;XIAO Cheng-yong;TAN Hong-ling;TANG Xiang-lin;ZHANG Bo-li;GAO Yue;Department of Pharmacology,Anhui Medical University;The Radiation Medical Institute,Academy of Military Medical Sciences;Tianjin University of Traditional Chinese Medicine;  
Objective To study the effects of Composite Salvia Recipe(CSR) and its single drugs on the main subtypes of cardiac cytochrome P450(CYPs) in rats. Methods Male SD rats were randomly divided into five groups, CSR [0.32 g/(kg·d)], Salvia miltiorrhiza [0.27 g/(kg·d)], Panax notoginseng [0.05 g/(kg·d)], borneol [0.003 g/(kg·d)], and physiological saline were ig given for 28 d, then the cardiac tissues were taken. The mRNA expression change of cardiac CYPs was detected by real time PCR. Results Compared with the control group, CSR could down-regulate the mRNA expression of CYP1B1, CYP2B1, CYP2E1, CYP4A1, and CYP4F4(P 0.05). S. miltiorrhiza could significantly down-regulate the mRNA expression of CYP1A1, CYP1B1, CYP2B1, CYP2C11, CYP2E1, CYP2J3, CYP4A1, CYP4F4, and CYP4F5(P 0.05, 0.01), while up-regulate the mRNA expression of CYP4A3, CYP4F1, and CYP4F6(P 0.05). P. notoginseng inhibited the mRNA expression of CYP1A1, CYP1B1, CYP2B1, CYP2C11, CYP2E1, CYP2J3, CYP4A1, CYP4A3, CYP4F4, CYP4F5, and CYP4F6(P 0.05, 0.01); Borneol could inhibit the mRNA expression of CYP1A1, CYP1B1, CYP2B1, CYP2C11, CYP4A1, and CYP4F4(P 0.01). Conclusion The study declares that the single drugs have more significant influences on the mRNA expression of CYP than CSR. CSR and its single drugs might protect heart, and its effect on CYP2 and CYP4 families might be bidirection regulation.
【Fund】: 国家重点基础研究发展计划(“973”计划)资助项目(2012CB518402)
【CateGory Index】: R285.5
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1 FAN Ling;TAN Cheng-bo;YIN Hui;Department of Electrocardiogram, Chengdu Military General Hospital;Department of Cardiovascular Internal Medicine, Chengdu Military General Hospital;;Clinical observation of Compound Danshen Dripping Pills combined with cinepazide maleate in treatment of unstable angina[J];现代药物与临床;2015-09
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