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《Chinese Traditional and Herbal Drugs》 2014-01
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Improvement of acteoside on cerebral injury in subacute aging mice induced by D-galactose

GAO Li;PENG Xiao-ming;HUO Shi-xia;LIN Juan;YAN Ming;ZHANG Fu-chun;Xinjiang Key Laboratory of Biological Resources and Genetic Enigneering,College of Life Science and Technology,Xinjiang University;Prescription Laboratory of Xinjiang Traditional Uyghur Medicine,Xinjiang Institute of Traditional Uighur Medicine;  
Objective To investigate the effect of acteoside on cerebral injury in subacute aging mice induced by D-galactose. Methods The aging model of mice was established by sc administration of D-galactose, taking learning, memory, index of immune organs, activities of choline acetyltransferase(ChAT) and acetylcholinesterase(AchE) in mice brain, and cell morphology of hippocampal CA1 region as indicators to study the effect. Results Compared with the model group, acteoside could recover the learning and memory capacity, resist immune organs atrophy, enhance the activity of ChAT, inhibit the activity of AChE, and improve the number and arrangement of cerebral pyramidal cells in hippocampal CA1 region. Conclusion Acteoside has remarkably reduced the crerebral injury of mice induced by D-galactose, and could increase the activities of ChAT and AchE in mice brain, protect the brain cells in hippocampal CA1 region, improve immune organs index, and enhance the learning and memory capacity. Acteoside has the protective effects on cerebral injury induced by D-galactose, and the mechanism may be related to the improvement of the central cholinergic system and the protection of nerve cells.
【Fund】: 新疆维吾尔自治区科研机构创新发展专项资金(2012015);; 新疆维吾尔自治区公益性科研院所基金(KY2012114)
【CateGory Index】: R285.5
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