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Chemical constituents from stems of Syzygium jambos var. jambos and their in vitro cytotoxicity

LIN Da-du;LIU Jia-wei;LI Wu-guo;LUO Wei;CHENG Jin-le;CHEN Wei-wen;Key Laboratory of Chinese Medicinal Resource from Lingnan (Ministry of Education), Research Center of Medicinal Plant Resource Science and Engineering, Guangzhou University of Chinese Medicine;Zhongzhi Pharmaceutical Company Group;Analysis and Test Center of South China University of Technology;  
Objective To study the chemical constituents from the stems of Syzygium jambos var. jambos. Methods The phyotchemicals were isolated by using various chromatographic techniques such as silica gel, Sephadex LH-20, alumina column chromatography, and preparative HPLC process. The structures were elucidated on the basis of spectral data analysis. Their cytotoxicity against human liver cancer cells Huh-7 was conducted using MTT assay. Results Twelve compounds were isolated from the EtOAc and MeOH extracts in the stems of S. jambos and identified as alphitolic acid(1), urolithin A(2), dibutyl phthalate(3), betulinic acid(4), ursolic acid(5), 1-(4-methoxyphenyl)-1, 2-propanediol(6), 2, 6-dimethoxy-1, 4-benzoquinone(7), diisobutyl phthalate(8), β-sitosterol(9), 3-acetyl-ursolic acid(10), asiatic acid(11), and arjunolic acid(12), respectively. All tested compounds 1, 7, 10, and 11 + 12 mixture did not show the cytotoxic activities towards human tumor cells Huh-7 in the test range up to 50 μmol/L. Conclusion Except compound 4, the other 11 compounds are obtained from this plant for the first time. All tested compounds exhibit no significant cytotoxic activity against Huh-7 cells.
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