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《Chinese Traditional and Herbal Drugs》 2015-01
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Optimization of preparation technology of colon-specific chitosan microspheres of rhubarb total anthraquinones

LIU Xi-gang;LIU Pei;CHEN Da-wei;CHANG Jin-hua;LI Zhong-si;LIU Li-yan;LIU Cui-zhe;Hebei Province Key Laboratory of Research and Development for Chinese Medicine, Chengde Medical College;College of Pharmacy, Shenyang Pharmaceutical University;  
Objective To optimize the preparation technology of colon-specific chitosan microspheres of rhubarb total anthraquinones(RTA-CMS). Methods With chitosan as material, RTA was made into microspheres. According to the entrapment efficiency(EE) and particle diameter, the best preparation technology was selected using orthogonal design. The enteric material Eudragit S100 was used to coat the CMS. Results The best preparation technology was as follows: The concentration of chitosan was 2.5%; The mass ratio of RTA and chitosan was 1∶4; The ratio of paraffin and dichloromethane was 1∶1; The amount of span-80 was 2%. The EE of CMS was 64.5%. The particle diameter of the CMS was(248.8 ± 54.2) μm, and the mean diameter was(269.3 ± 172.7) μm after coating. Conclusion RTA-CMS prepared with the best preparation technology has a high EE. And the microspheres form is good. The technology could be used to prepare colon-specific RTA-CMS.
【Fund】: 国家自然科学基金资助项目(81073146 81341143);; 河北省高等学校科学技术研究重点项目(ZH2012050);; 河北省高校重点学科建设项目
【CateGory Index】: R283.6
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