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《Chinese Traditional and Herbal Drugs》 2015-01
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Identification of MicroRNAs from Eurya chinensis and function analysis on their target genes

FANG Jie;HU Yi-xiang;YING Hua-zhong;YU Wen-ying;JIN Xiao-yin;YU Chen-huan;Pharmacy College, Zhejiang Chinese Medical University;Zhejiang Key Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences;  
Objective To investigate the pharmacodynamic Micro RNAs(mi RNAs) in Eurya chinensis and the functions of their target genes. Methods The mi RNA profiles of E. chinensis in liver and plasma of normal mice and E. chinensis extract-treated mice were detected using high-flux sequencing, and then the mi RNAs which took into the organism were validated by RTFQ-PCR using plant mi RNA database in Gene Bank. Human m RNA database as target was used to predict the target genes of mi RNAs by Target Scan and Mi Randa analysis, while the target gene functions were considered by GO and KEGG analyses. Results Five pharmacodynamic micro RNAs were identified and took part in biological processes, cellular components, and molecular functions, which affected tumor, metabolism, and inflammation-related signal pathways. Conclusion The mi RNAs might act as new pharmacodynamic materials of Chinese materia medica.
【Fund】: 国家自然科学基金资助项目(81202977 81473339);; 浙江省卫生高层次创新人才项目
【CateGory Index】: R285.5
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