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《Chinese Traditional and Herbal Drugs》 2016-02
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Optimization of processing technology for Psoraleae Fructus by D-optimal response surface methodology with UHPLC

LI Na;ZHANG Xiao-mei;YAO Yuan-yuan;CHEN Yi-long;FAN Qi;School of Pharmacy, Chongqing Medical University;Chongqing Academy of Chinese Materia Medica;  
Objective To optimize the processing technology for Psoraleae Fructus by D-optimal response surface methodology with UHPLC. Methods Based on the content variations of nine main constituents(psoralen, isopsoralen, neobavaisoflavone, bavachin, psoralidin, corylifolinin, corylin, bavachalcone, and bakuchiol) determined by UHPLC, the D-optimal response surface methodology combined with single factor experiment was used to optimize the moistened time, stir-fried temperature, salted dosage, and stir-fried time in the processing technology for Psoraleae Fructus. Results The optimal processing technology for Psoraleae Fructus was as follows: 100 g Psoraleae Fructus was mixed with 2.10 g salt, moistened for 12 h, and stir-fried for 30 min at 80 ℃. Conclusion The processing technology for Psoraleae Fructus optimized by D-optimal response surface methodology with UHPLC could be used to optimize the process parameters, to promote the stability and repeatability of the processing technology, which provides the technique support for improving the quality uniformity of Psoraleae Fructus and safety in clinic application.
【Fund】: 重庆市“121”科技支撑示范工程项目(cstc2012jcsf-jfzh X0029);; 重庆市基本科研业务费计划项目(cstc2015ja15-24);; 重庆市卫生局中医药科技项目(ZY20132068)
【CateGory Index】: R283
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