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《Chinese Traditional and Herbal Drugs》 2016-02
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Preparation of glycyrrhetinic acid niosomes and optimization of its prescription process

LI Xi-xiang;ZHANG Ya-hui;LIU Xiao-shuan;BAO Qiang;QIAN Meng-ru;Gansu Province Hospital of Chinese Medicine;Gansu University of Chinese Medicine;  
Objective With nonionic surfactants as the carrier material to prepare glycyrrhetinic acid(GC) niosomes(NI) and to evaluate the quality. Methods The thin film dispersion-ultrasound method was used for establishing the preparation process of GC-NI, reverse dialysis method and ultraviolet spectrophotometer method were used to determine the encapsulation efficiency(EE), the prescription and preparation process were optimized through single factor and central composite design-response surface methodology(CCD-RSM), and the properties of morphology, particle size, Zeta potential, and EE in optimized NI were investigated. Results The optimum prescription process as Span 80-cholesterol was 2∶1, hydration temperature was 70 ℃, hydration time was 51 min, ultrasonic time was 60 min, its forecast EE was 80.66%, bias between the observed and predicted values was 4.95%, and regression coefficient of binomial fitting complex model was as high as 0.989 9. Conclusion CCD-RSM is used to optimize the preparation, which has the stable, feasible, high precision, and good predictability advantage.
【Fund】: 甘肃省科技支撑计划——甘草次酸口服囊泡包裹的纳米载体构建及肝靶向特性研究(1204FKCA183)
【CateGory Index】: R283.6
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