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《Chinese Traditional and Herbal Drugs》 2016-02
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Research progress on co-crystal of insoluble active ingredients of Chinese materia medica

ZHOU Xin-bo;WU Su-xiang;SUN Meng-ying;HU Xiu-rong;College of Pharmaceutical Science, Zhejiang University of Traditional Chinese Medicine;Department of Chemistry, Zhejiang University;  
Co-crystal is a crystalline structure composed of at least two components, where the components may be active pharmaceutical ingredients(APIs) and co-formers in stoichiometric amounts. Co-crystal structure exhibits long range order and the components interact via non-covalent interaction such as hydrogen bonding, ionic interaction, vander-waals interaction, and π-π interaction. The intermolecular interaction and resulting crystal structure can generate physicochemical properties which differ from the properties of the individual components. Such properties include melting point, solubility, chemical stability, and mechanical properties. Meanwhile, co-crystal can break through patents protection of APIs. So co-crystal attracts more attention in pharmaceutical research and development field. With the development of pharmaceutical co-crystals, there may be an opportunity for improving the insoluble active ingredients of Chinese materia medica(CMM) in further development. This review has been organized around four categories: the co-crystals of flavonoids(I), alkaloids(II), terpenes(III), and polyphenols(IV) and their effects on physicochemical properties and bioavailability of those APIs, which provide a good reference for the application of pharmaceutical co-crystals in insoluble active ingredients of CMM.
【CateGory Index】: R284
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Chinese Journal Full-text Database 4 Hits
1 REN Tiankun;ZHANG Yurui;LIU Xiaoya;WANG Jing;YANG Caiqin;Pharmaceutical College, Hebei Medical University;;Preparation and Thermodynamics of Oleanolic Acid Co-crystals[J];中国医药工业杂志;2014-07
2 HAO Hai-jun;ZHANG Hong-qin;JIA You-zhi;HAN Ru;WANG Hang;State Key Laboratory of New Drug and Pharmaceutical Process,Shanghai Institute of Pharmaceutical Industry;National Engineering Research Center for Traditional Chinese Medicine;The 152 Central Hospital of PLA;;Progress in research on enhancing dissolution and bioavailability of Chinese materia medica-phospholipid complex with new preparation techniques[J];中草药;2013-17
3 YUN Bao-yi,ZHOU Lei,XIE Kun-peng,WANG Ye-ju,XIE Ming-jie(College of Life Science,Liaoning Normal University,Key Laboratory of Biotechnology and Drug of Liaoning Province,Dalian 116029,China);Antibacterial activity and mechanism of baicalein[J];药学学报;2012-12
4 HE Wen-bin~(1,2),ZHANG Jun-long~1,XUE Wei~2,HU Jin-feng~2,WANG Xiao-feng~2,CHEN Nai-hong~2 (1 Shanxi College of Traditional Chinese Medicine,Taiyuan 030024,China;2 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China);Flavonoid myrisetin promotes long-term potentiation in rat hippocampal CA1 region in vivo[J];中国新药杂志;2009-24
Chinese Journal Full-text Database 10 Hits
1 WANG Xin;ZHANG Rui;LI Ya-jing;DONG Qian-qian;Department of Clinical Laboratory,the Second Hospital of Hebei Medical University;;Antibacterial and Ultrastructure Effect of RES on Staphylococcus Aureus Standard Strains ATCC 25923[J];现代检验医学杂志;2016-03
2 Tian Shuo;School of Pharmacy,Harbin University of Commerce;;Recent Advances in Pharmacological Effects and Molecular Mechanisms of Baicalein[J];黑龙江医药;2015-06
3 XU Dongwei;LIU Tongxiang;Department of Pharmacy, Hospital of Central University for Nationalities;Department of Medicinal Chemistry, Institute of Minority Traditional Chinese Medicine of Central University for Nationalities;;Preparation of Baicalein Liposome-lyophilized Powder and its preliminary evaluation[J];中国医药导报;2015-34
4 YU Tong;JI Peng;ZHAO Wen-ming;Department of Pharmaceutics,School of Pharmaceutical Sciences,Liaoning Medical University;;Preparation of Baicalein Liposome-Lyophilized Powder and Its Pharmacokinetics Study[J];中药材;2015-11
5 LI Meng-Miao;XIE Kun-Peng;SUI Jia-Qi;XIE Ming-Jie;School of Life Sciences,Liaoning Normal University,Key Laboratory of Biotechnology and Drug Discovery of Liaoning Province;;Antibacterial Mechanism of Ethanolic Extract of Hibiscus sabdariffa Against Escherichia coli and Staphylococcus aureus[J];中国生物化学与分子生物学报;2015-10
6 WU Xian-chuang;HAO Hai-jun;ZHANG Yong-zhou;SONG Xiao-yong;LIU Yu-xin;ZHANG Hong-qin;Huaihe Hospital of Henan University;Shanghai Institute of Pharmaceutical Industry;National Engineering Research Center for Traditional Chinese Medicine;;The bioavailability influence of oral curcumin-phospholipid complex preparations on SD rats[J];中成药;2015-10
7 YU Tong;WU Chao;JI Peng;XU Jie;ZHAO Ying;HAO Yan-na;ZHAO Wen-ming;WANG Tie-liang;College of Pharmacy, Liaoning Medical University;College of Animal Husbandry and Veterinary, Liaoning Medical University;;Preparation and in vitro release of lyophilized powder of baicalein solid lipid nanoparticles[J];中草药;2015-18
8 HUANG Xiangzhen;GUAN Haofeng;Department of Pharmaceutical,Jiangmen Central Hospital in Guangdong Province;Department of Paediatrics,Jiangmen Central Hospital in Guangdong Province;;Clinical analysis of compound cordate houttuynia mixture combined with cefaclor in the treatment of children with pneumonia[J];中国现代医生;2015-24
9 LIU Yun-ning;LI Xiao-feng;BAN Xu-xia;Department of Pharmacy,The First Affiliated Hospital of Hebei North University;;The review on active antibacterial ingredients of Chinese medicine and the antibacterial mechanism[J];环球中医药;2015-08
10 CHAI Lianmei;MA Lianjun;DU Feng;Department of Gynecology,Shouguang Maternal and Child Care Service Centre;Department of Obstetrics,Traditional Chinese Medicine Hospital of Weifang;;Clinical research on traditional Chinese medicine of Quyoufang washout therapy on condyloma acuminatum in gestational period[J];中国性科学;2015-07
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 TANG Qin,SUN Xiao-hui,CHEN Hao,XU Xiao-yu,ZHANG Ji-fen The Engineering and Technology Center of Efficacy Evaluation in Chongqing,College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China;Effects of preparation methods and technologies on in vitro characteristics of curcumin-phospholipid complex-chitosan microspheres[J];中草药;2012-12
2 LI Yan-zhen,YAN Hui,LIU Huan,JIN Wen-xian,WANG Cheng-gang State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin300193,China;Preparation of vinorelbine-phospholipid complex and its characterization[J];现代药物与临床;2012-06
3 CHEN Xuewen1,2,SONG Ju1,2,TANG Haiyi3,ZHENG Ying1,2(1.State Key Lab.of Quality Research in Chinese Medicine(University of Macau),Macao SAR 999078; 2.Institute of Chinese Medical Sciences,University of Macau,Macao SAR 999078; 3.School of Health Sciences,Macao Polytechnic Institute,Macao SAR 999078);Progress in Screening Methods and Physicochemical Properties of Pharmaceutical Co-crystals[J];中国医药工业杂志;2012-08
4 TONG Li-jiao1,GAO Min2,HOU Gui-lan3,WANG Xin-bo1,SHI Sen-lin2 1.Lin’an Hospital of Traditional Chinese Medicine,Lin’an 311300,China 2.College of Pharmacy,Zhejiang Chinese Medical University,Hangzhou 310053,China 3.Zhejiang Cancer Hospital,Hangzhou 310022,China;Influencing factors on stability of hawthorn leaves total flavonoids-phospholipid complex[J];中草药;2012-05
5 LIU Shan 1,TAN Qun-you2,WANG Hong1,LIAO Hong1,ZHANG Jing-qing1(1.Medicine Engineering Research Center,Chongqing Key Laboratory of Biochemical & Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,China;2.Department of Thoracic Surgery,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Preparation,Characterization and in Vitro Anti-Tumor Activities of Evodiamine Phospholipids Complex[J];中国药学杂志;2012-07
6 WU Hui-yi,LONG Xiao-ying,CHEN Li,LI Zhi-heng,PAN Su-jing School of Traditional Chinese Materia Medica,Guangdong Pharmaceutical University,Guangzhou 510006,China;Phospholipid complex and its effect on membrane transport of active constituents of Chinese materia medica[J];中草药;2012-02
7 SHI Ya-jun1,3,WU Pin-jiang1,XU Run-chun1,LIN Yan-jun1,MA Hong-yan1,YANG Ming1,2 1.College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China 2.Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China 3.College of Pharmacy,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China;Basic property of baicalin-phospholipid complex[J];中草药;2012-01
8 LI Nan1,2,YE Ying-jie1,YANG Ming3,JIANG Xue-hua2,XU Run-chun1(1.Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;2.West China School of Pharmacy,Sichuan University,Chengdu 610041,China;3.Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Nanchang 330004,China);Evaluation of Brain-Targeting of Nasal Baicalin-Phospholipid Complex in Situ Gel[J];中国药学杂志;2011-16
9 ZHENG Qin,YUE Pengfei,WANG Musheng,WANG Fang,YANG Ming(Key Lab.of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004);Preparation and Characterization of Geniposide-Phospholipid Complex[J];中国医药工业杂志;2011-03
10 Lu Guoqing1,2,Zheng Jiang3,Zheng Xinchuan3,Lu Yonglin3,He Fengci1(1Division of Scientific Research Affairs,3Medical Research Center,Southwestern Hospital,Third Military Medical University,Chongqing,400038;2 Department of Clinical Pharmacy,General Hospital of Chengdu Military Command,Chengdu,Sichuan Province,610083,China);Preparation and characterization of oridonin phospholipid complex[J];第三军医大学学报;2010-20
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