Historical story on natural medicinal chemistry: Determination of absolute configuration of natural products by Mosher's method
LI Li-geng;WANG Yu-fang;FU Yan;LV Tao;GU Yu-cheng;SHI Qing-wen;College of Pharmaceutical Sciences,Hebei Medical University;Jealott's Hill International Research Centre;
Determination of the absolute configuration is considered one of the most complicated works in the natural products study. Mosher's method provides a practical solution for the stereochemistry determination of natural products by means of NMR spectroscopy. This article, which reviews the classic application of Mosher's method, is one of the series of historical stories on natural product chemistry published in this journal.