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Study on visualization of metabolic process of L-stepholidine in living rats by PET/CT in vivo

TAN Hai-bo;ZHANG Zheng-wei;GUAN Yi-hui;LIN Xiang-tong;PET Center Huashan Hospital,Fudan University;  
Objective To exolpre the feasibility to transform the metabolic process of active constituents of Chinese herbal medicine in vivo into images by PET/CT and to make quantitative analysis. Methods The l-stepholidine was used as study object, and chemical synthesis of 11C-L-SPD was performed in hot room. PET/CT scan was performed in different time, 5, 15, 30, 45, 60, and 90 min after injecting 11C-L-SPD by vail in rats, and the information of brain, heart, lung, liver, kidney, intestine, and bladder was transferred to the Workststion. The distribution volume ratios(DVR) of the above tissues were obtained. Results 11C-L-SPD was keeping in a relative higher level in liver and kidney at 5 min. metabolism through the liver, kidney was the main eccrisis organ. The distribution of 11C-L-SPD in liver, kidney, intestine, and bladder was(1.37 ± 0.42)%,(1.10 ± 0.19)%,(0.89 ± 0.18)%, and(0.97 ± 0.111)% respectively at 5 min and was(0.65 ± 0.11)%,(0.54 ± 0.05)%,(5.49 ± 1.44)%, and(9.86 ± 1.88)% respectively at 90 min. Conclusion PET/CT imaging could observe the distribution and metabolism of 11C-L-SPD dynamically and directly. It could be used in the research of other Chinese medicines.
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