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《浙江大学学报(英文版)》 2005-01
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Investigating the role of~(99m)Tc-TRODAT-1 SPECT imaging in idiopathic Parkinson's disease

GENG Yu SHI Guo-hua JIANG Yun XU Ling-xun HU Xing-yue SHAO Yu-quan~1Department of Neurology~2Department of Nuclear Medicine,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China~3Department of Nuclear Medicine,Shanghai Hospital Affiliated Second Military Medical University,Shanghai 200433,China  
Objective:To investigate the role of ~(99m)Tc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathicParkinson's disease(PD).Methods:Thirty-eight patients with primary,tentative diagnosis of PD and eighteen age-matchednormal controls were studied with ~(99m)Tc-TRODAT-1 SPECT imaging.The regions of interests(ROIs)were drawn manually oncerebellum(CB),occipital cortex(OC)and three transverse plane slice-views of striatums,the semiquantitative BG(back-ground)/[(OC+CB)/2]were then calculated.Results:A lower uptake of ~(99m)Tc-TRODAT-1 in striatums were displayed inthirty-six out of thirty-eight PD patients by visual inspection,compared to controls.In twenty-four PD cases with HYS(Hoehn andYahr scale)stage Ⅰ,a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affectedlimbs than in the same regions of the controls,although the striatal uptake was bilaterally reduced.Using Spearman correlationanalysis showed that the reduction of the uptake ratios significantly correlated with the UPDRS in striatum and all its subregions inthe PD group(P0.05),a similar change was also found in the putamen by using the rating scale of Hoehn and Yahr (P0.05).However,analysis of variance(ANOVA)did not show any relationship between the decreasing uptake of ~(99m)Tc-TRODAT-1 andincreasing severity of PD patients,although the specific uptake of ~(99m)Tc-TRODAT-1 was continuously decreased in the striatumby visual inspection with the progress of PD from HYS stage Ⅰ to Ⅲ.Conclusion:~(99m)Tc-TRODAT-1 SPECT imaging may serve asa useful method for improving the correct diagnosis of PD.In assessing the role of ~(99m)Tc-TRODAT-1 SPECT in disease severity ofPD,UPDRS can offer a comprehensive index,although the Hoehn and Yahr assessment may be available in part.
【CateGory Index】: R817.4
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