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《浙江大学学报(英文版)》 2005-01
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Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients:Neopterin and Interleukin-2

YAN Min CHEN Gang FANG Ling-ling LIU Zi-ming ZHANG Xiu-lai (Department of Anesthesiology.Second Affiliated Hospital.School of Medicine.Zhejiang University.Hangzhou 310009.China  
Objective:To estimate the impact of autologous transfusion on the status of perioperative immune activation inmalignant tumor patients.The Serum Neopterin and Interleukin-2(IL-2)were measured.Methods:Sixty patients undergoingelective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups:(Ⅰ)Group A received autologous transfusion;(2)Group H received allogeneic transfusion.The perioperative course(Beforeinduction of anesthesia,after operation and 5 d after operation)of Neopterin and IL-2 was compared.Results:In group A,SerumNeopterin was significantly lower than baseline alter operation and IL-2 had no significant changes.In group H,both SerumNeopterin and IL-2 were significantly lower than baseline alter operation and 5 d after operation.Compared with group A,SerumNeopterin was significantly lower than baseline alter operation and 5 d after operation and IL-2 was significantly lower thanbaseline 5 d alter operation.Conchision:Autologous transfusion decreased the perioperative immune suppression in malignantstomach tumor patients.
【Fund】: Project(No.1121) supportedbyZhejiangProvinceHealthBueau China
【CateGory Index】: R730.5
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