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《浙江大学学报(英文版)》 2005-01
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Oxidative stress and damage induced by abnormal free radical reactions and IgA nephropathy

CHEN Jia-xi~+ ZHOU Jun-fu SHEN Han-chao (Division of Nephrology.Second Affiliated Hospital.School of Medicine.Zhejiang University.Hangzhou 310009.China)  
Objective:To estimate the oxidative stress and oxidative damage induced by abnormal free radical reactions in IgAnephropathy(IgAN)patients' bodies.Methods:Seventy-two IgA N patients(IgANP)and 72 healthy adult volunteers(HAV)wereenrolled in a random control study design,in which the levels of nitric oxide(NO)in plasma,lipoperoxide(LPO)in plasma and inerythrocytes,and vitamin C(VC),vitamin E(VE)and β-carotene(β-CAR)in plasma as well as the activities of superoxide dis-mutase(SOD),catalase(CAT)and glutathione peroxidase(GPX)in erythrocytes were determined with spectrophotometricmothods.Results:Compared with the HAV group,the averages of NO in plasma,and LPO in plasma and in erythrocytes in theIgANP group were significantly increased(P0.0001),while those of VC,VE and β-CAR in plasma as well as those of SOD,CATand GPX in erythrocytes in the IgANP group were significantly decreased(P0.0001).Linear correlation analysis showed thatwith the increase of the values of NO,and LPO in plasma and in erythrocytes,and with the decrease of those of VC,VE,β-CAR,SOD,CAT and GPX in the IgAN patients,the degree of histological damage of tubulointerstitial regions was increased gradually(P0.0001):and that with the prolongation of the duration of disease the values of NO,and LPO in plasma and erythrocytes wereincreased gradually,while those of VC,VE,β-CAR, SOD,CAT and GPX were decreased gradually(P0.005).The discrimina-tory correct rates of the above biochemical parameters reflecting oxidative damage of the IgAN patients were 73.8%-92.5%,andthe correct rates for the HAV were 70.0%-91.3% when independent discriminant analysis was used;and the correct rate for theIgAN patients was increased to 98.8%,the correct rate for the HAV was increased to 100% when stepwise discriminant analysiswas used.The above biochemical parameters' reliability coefficient(alpha)were used to estimate the oxidative damage of theIgAN patients as 0.8145,the standardized item alpha 09730,F=53273.5681,P0.0001.Conclusions:A series of free radicalchain reactions caused serious pathological aggravation in the IgANP' bodies,thus resulting in oxidative damage in their bodies.Intreating IgANP,therefore,it is necessary that suitable dose antioxidants should be supplemented to them so as to alleviate theoxidative damage in their bodies.
【CateGory Index】: R692.31
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