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《浙江大学学报(英文版)》 2005-01
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Separation and identification of cis and trans isomers of 2-butene-1,4-diol and lafutidine by HPLC and LC-MS

PAN Chun-xiu XU Xiu-zhu HE Hong-mei CAI Xiao-jun ZHANG Xue-jun (Department of Chemistry,Zhejiang University,Hangzhou 310027,China)  
The cis and trans isomers separation of 2-butene-1,4-diol and lafutidine were studied by HPLC on two kinds of chiralcolumns:(S,S)-Whelk-O 1 and ChiraSpher.The isomers of 2-butene-1,4-diol can be separated on both chiral columns while theisomers of lafutidine can only be resolved on ChiraSpher column.The influence of different type and amount of mobile phasemodifier on the isomers separation was extensively studied.The resolution of cis and trans isomers of 2-butene-1,4-diol was 2.61on(S,S)-Whelk-O 1 column with hexane-ethanol(97:3,v/v)as the mobile phase.The resolution of lafutidine was 1.89 onChiraSpher column with hexane-ethanol-THF-diethylamine(92:3:5:0.1,v/v/v/v)as the mobile phase.LC-MS methods weredeveloped to identify the isomer peaks.
【Fund】: Project(No.03111) supportedbytheFoundationofAnalysis&MeasurementofZhejiangProvince China
【CateGory Index】: O657.63
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Wei qiang,XU De yi (Department of pharmacology, Basic Medical College, Southeast University, Nanjing JIANGSU 210009, China);Lafutidine, a novel antiulcer drug[J];Chinese Journal of New Drugs and Clinical Remedies;2003-04
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 ZHENG Yong~1,CHEN Mei~1,ZHAO Chun-jing~1,et al(1.The Second Hospital of Chongqing University of Medical Sciences,Chongqing 410010,China;2.The Children's Hospital of Chongqing University of Medical Sciences,Chongqing 400014,China);Determination of lafutidine in serum with reverse high performance liquid chromatography[J];Journal of Pediatric Pharmacy;2006-03
2 Luo Lifang Tian Yuan Guo Huimin Zhang Zunjian *(1.Key Laboratory of Drug Quality Control and Pharmacovigilance(Ministry of Education),China Pharmaceutical University,Nanjing 210009);Pharmacokinetic interaction between ibuprofen and lafutidine in rats[J];Journal of North Pharmacy;2013-06
3 ZHU Ren-fa~1,WANG Xiao-shan~2,YU Han-qing~1(1.Dept.of Chemistry,University of Science and Technology of China,Hefei 230026,China;2.School of Pharmaceutical,Anhui College of Traditional Chinese Medicine,Hefei 230031,China);Synthesis of the novel histamine 2 H_2-receptor antagonist—lafutidine[J];Journal of Hefei University of Technology(Natural Science);2005-10
4 SHANGGUAN Ying-ying,SHI Jing,CHEN Xiao-lin,HE Xian-chen (Zhejiang Medical College,Hangzhou 310053,China);Determination of residual organic solvents in Lafutidine by GC[J];West China Journal of Pharmaceutical Sciences;2005-04
5 SHANGGUAN Ying-ying~1,SHI Jing~1,HE Xian-chen~1,HU Xiu-ai~2(1.Zhejiang Medical College, Hangzhou 310053,China;2.Hangzhou Desheng Pharmceutical Development Co.Ltd., Hangzhou 310014,China);Determination of related substance in lafutidine by RP-HPLC[J];The Chinese Journal of Modern Applied Pharmacy;2005-04
6 SHEN Qian,YANG Yang,BAI Xiang-rong,LI Huan-ming,WANG Yu-qin (Dept.of Pharmacy,Xuanwu Hospital,Capital Medical University,Beijing 100053,China);Pharmacokinetic Study of Lafutidine Capsule in Healthy Volunteers[J];China Pharmacy;2010-34
7 FENG Qi-lin,WANG Ying,WANG Yi(Wuhan Central Hospital,Wuhan 430014,China);Efficacy Observation of Lafutidine Combined with Omepazole in the Treatment of Non-steroidal Anti-inflammatory Drugs Induced Peptic Ulcer[J];China Pharmacy;2012-20
8 Yu Jun1,Zhang Li2,Xu Guobing3(1.Xuancheng Institute for Food and Drug Control,Xuancheng 242000;2.Anhui University of Traditional Chinese Medicine,Hefei 230008;3.Anhui Institute for Food and Drug Control,Hefei 230001);Determination of Nizatidine,Cimetidine,Famotidine,Ranitidine Hydrochloride and Lafutidine illegally mixed into ShiliuJianwei Capsules[J];Drug Standards of China;2012-02
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