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《浙江大学学报(英文版)》 2005-01
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Separation and identification of cis and trans isomers of 2-butene-1,4-diol and lafutidine by HPLC and LC-MS

PAN Chun-xiu XU Xiu-zhu HE Hong-mei CAI Xiao-jun ZHANG Xue-jun (Department of Chemistry,Zhejiang University,Hangzhou 310027,China)  
The cis and trans isomers separation of 2-butene-1,4-diol and lafutidine were studied by HPLC on two kinds of chiralcolumns:(S,S)-Whelk-O 1 and ChiraSpher.The isomers of 2-butene-1,4-diol can be separated on both chiral columns while theisomers of lafutidine can only be resolved on ChiraSpher column.The influence of different type and amount of mobile phasemodifier on the isomers separation was extensively studied.The resolution of cis and trans isomers of 2-butene-1,4-diol was 2.61on(S,S)-Whelk-O 1 column with hexane-ethanol(97:3,v/v)as the mobile phase.The resolution of lafutidine was 1.89 onChiraSpher column with hexane-ethanol-THF-diethylamine(92:3:5:0.1,v/v/v/v)as the mobile phase.LC-MS methods weredeveloped to identify the isomer peaks.
【Fund】: Project(No.03111) supportedbytheFoundationofAnalysis&MeasurementofZhejiangProvince China
【CateGory Index】: O657.63
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Chinese Journal Full-text Database 1 Hits
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