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《浙江大学学报(英文版)》 2005-11
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Acute phase reaction and acute phase proteins

GRUYS E.1, TOUSSAINT M.J.M.1, NIEWOLD T.A.2, KOOPMANS S.J.2 (1Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands) (2Animal Sciences Group, Wageningen University Research, Lelystad, the Netherlands)  
A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given. It appears that APPs represent appropriate analytes for assessment of animal health. Whereas they represent non-specific markers as biological effect reactants, they can be used for assessing nutritional deficits and reactive processes, especially when positive and negative acute phase variables are combined in an index. When such acute phase index is applied to separate healthy animals from animals with some disease, much better results are obtained than with single analytes and statistically acceptable results for culling individual animals may be reached. Unfortunately at present no cheap, comprehensive and easy to use system is available for assessing various acute phase proteins in serum or blood samples at the same time. Protein microarray or fluid phase microchip technology may satisfy this need; and permit simultaneous analysis of numerous analytes in the same small volume sample and enable integration of information derived from systemic reactivity and nutrition with disease specific variables. Applying such technology may help to solve health problems in various countries not only in animal husbandry but also in human populations.
【Fund】: The paper presented at the 28th Seminar on Recent Advances inAnimal Health and Production University Putra Malaysia KualaLumpur Malaysia March 28th 2005
【CateGory Index】: R363;
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【References】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Hai-Tao1,ZHU Hong2,LIU Jian-Jun3,XU Jing4,LI-LING Jesse5,JIA Shao-Wei1,LIU Peng-Cheng1(1.Shenzhen Hospital,Peking University,Shenzhen 518036,China;2.Chronic Disease Prevention andCure Station of Futian District,Shenzhen 518048,China;3.Shenzhen Center for DiseasePrevention and Control,Shenzhen 518020,China;4.Shenzhen DetoxificationCenter,Shenzhen 518019,China;5.Department of Medical Genetics,China Medical University,Shenyang 110001,China);Proteomic analysis of plasma from heroin abusers under immobilized pH gradients 4-7[J];Chinese Journal of Pharmacology and Toxicology;2008-04
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Tian Xin CHU1, *, Judith A LEVY2 1Beijing Center for Disease Prevention and Control, 16 Hepingli Middle Street, Beijing 100013, China 2University of Illinois at Chicago, School of Public Health, 1603 West Taylor St., Chicago, IL 60612 USA;Injection drug use and HIV/AIDS transmission in China[J];细胞研究(英文版);2005-Z1
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