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A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells

Zuo-fu PENG1,Lin-xiang LAN1,Fang ZHAO1,Jing LI1,Qiang TAN2,Han-wei YIN3,Hui-hui ZENG1 (1Department of Chem-Biology,School of Pharmaceutical Sciences,Peking University,Beijing 100083,China) (2Department of Geriatric Medicine,Peking University First Hospital,Beijing 100034,China) (3College of Life Sciences,Peking University,Beijing 100075,China)  
Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone)ethane (BBSKE),a novel TrxR inhibitor,were investigated on human leu-kemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich’s ascites carcinoma-bearing mice were used to inves-tigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.
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