Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

Li SHI §1,Xiao-qin HUANG §1,Lei SHI 1,Yu-fen TAO 1,Yu-feng YAO 1,Liang YU 1,Ke-qin LIN 1,Wen YI 1,Hao SUN 1,Katsushi TOKUNAGA 2,Jia-you CHU 1 (1 Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College,Kunming 650118,China) (2 Department of Human Genetics,Graduate School of Medicine,University of Tokyo,Tokyo 113-0033,Japan)  
A study of the human leukocyte antigen (HLA) genetic characteristics in the Zhuang,the largest ethnic population in China,would provide insight into Zhuang history and give a useful tool for disease associations,transplantation,and anthropology.In the present study,we report the comprehensive HLA-A,HLA-B,HLA-C,and HLA-DRB1 alleles and haplotypes in the Zhuang population of southern China for the first time.A total of 13 HLA-A,24 HLA-B,22 HLA-C,and 18 HLA-DRB1 were identified in 104 Zhuang individuals.The frequencies of HLA-A11:01,A02:07,A24:02,A02:03,and A33:03 on A loci,B15:02,B58:01,B46:01,and B13:01 on B loci,C03:04,C08:01,C01:02,C03:02,and C07:02 on C loci,and DRB115:01,DRB116:02,DRB114:01,DRB115:02,and DRB103:01 on the DRB1 loci were 10%.The A33:03-C03:02-B58:01-DRB103:01 and A02:07-C01:02B46:01-DRB114:01 haplotypes were predominant in the Zhuang.The phylogenetic tree,as well as the analysis of haplotypes,suggested that the Zhuang are genetically similar to southern Chinese populations,especially the Zhuang-Dong language-speaking populations,such as the Bouyei,Dai,and Maonan.Even though the Zhuang and southern Chinese populations shared common alleles and haplotypes,the Zhuang has maintained its unique genetic characteristics.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved