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《Chinese Medical Record》 2008-01
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The Correlation between MMP-2 expression and Gastric Cancer Invasion and Metastasis

Xue Hongpeng, Lu Yixia, Heilongjiang Provincial Hospital for Digestive Diseases, Ha'erbing, 150000 Zhou Zhaohai, The First Hospital of Mudanjiang, Heilongjiang Province, 157000  
Objective To investigate the correlation between the expression of matrix metalloproteinase (MMP-2) and degree of invasion and lymph node metastasis. Method S-P immunohistochemical method was used to detect gastric cancer tissue MMP-2 expression in 78 cases. Result There was significant correlation between MMP-2 expression degree and pathological staging of early stage gastric cancer and progressive gastric cancer (P0.01), as well as lymph node metastasis(P0.01).Conclusion There was significant correlation between MMP-2 expression degree and gastric cancer staging and lymph node metastasis, MMP-2 expression degree is a valuable index for the judgment of gastric cancer stage and metastasis.
【CateGory Index】: R735.2
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