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《Chinese Medical Record》 2012-03
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Immune Effect of Liposomes Coating CpG ODN and Tumor Antigen for Liver Cancer Treatment

Si Xiaognag,Yang Jiada,Huang Ling,Medical College,Jinggangshan University,Ji'an 343000,Jiangxi Province,China  
Objectives This article discussed the immune effect of combination application of liposomal,CpG oligodeoxynucleotide(ODN) and Hepa 1-6 hepatoma cell lysates for liver cancer treatment.Methods Liver cancer model of C57BL/6 mice was set up.Tumor-bearing mice were subcutaneously injected PBS,ODN + Hep,Lip + ODN + Hep treatment and observation.Liver of different group mice used HE staining.FCM detected the formation of spleen CD3-FITC,CD4-FITC,CD8-FITC,NK1.1-FITC.The serum of mice immunized with IFN-γ,I L-4 level was measured by ELISA method.Results The destruction to competence in vitro of liposomes coating CpG ODN + Hepa 1-6 and CD3-FITC、CD4-FITC 、CD8-FITC、NK1.1-FITC in lysate of liver cancer cells and level of IFN-γ、IL-4 in mice serum are much higher than in CpG ODN + Hep group and PBS group.Conclusions Liposomal CpG ODN and Hep can significantly improve immune function,especially the specific cellular immune function.
【CateGory Index】: R735.7
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