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《Molecular Cardiology of China》 2011-01
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Cardiovascular response to coronary angiography in patients with obstructive sleep apnea

LUO Qin*, QIN Chun-Chang, LIU Zhi-Hong, ZHAO Zhi-Hui ZHANG Hong-Liang, YANG Yue-Jin. *Center for Pulmonary Vascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, China. Corresponding author: LIU Zhi-Hong  
Backgroud: Obstructive sleep apnea syndrome (OSA) is very common disease, which increases risks for the development of cardiovascular diseases. However, the underlying mechanisms are not understood. We aimed to observe whether patients with OSA had unfavorable cardiovascular responses to stress, which were risk factors for the development of hypertension.Methods: A retrospective study was carried out to observe OSA patients’ responses to stress through comparing their blood pressure and heart rate changes before, during and after coronary angiography in the sleep laboratory of center for pulmonary vascular diseases, Fuwai Hospital. Results: Fifty-six coronary artery disease patients with OSA and 18 coronary artery disease patients without OSA (No-OSA) were enrolled. In OSA patients, systolic blood pressure response to coronary angiography was exaggerated and diastolic blood pressure recovery was delayed compared with the No-OSA (P=0.047). No differences were noted in the heart rate response to coronary angiography between two groups. The increase in SBP during CAG was negatively correlated to 90% SaO2 (r=-0.222, p=0.031) and positively correlated to sleepiness score (r=0.257, p=0.028), but not related to AHI, ODI, and the lowest SaO2.Conclusions: Cardiovascular responses to coronary angiography in OSA patients were abnormal, reflected by an exaggerated systolic blood pressure response and delayed diastolic pressure recovery, which were associated with hypoxia and may play a role in cardiovascular complications of OSA patients.
【CateGory Index】: R766
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 FENG Xue-wei KANG Jian WANG Zan-feng WANG Qiu-yue YU Run-jiang Institute of Respiratory Diseases,First Hospital of China Medical University,Shenyang 110001,China;Regulation of hypothalamus-pituitary-adrenal axis and growth hormone axis in obstructive sleep apnea-hypopnea syndrome patients[J];中华结核和呼吸杂志;2006-04
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 Xu Jiahuan;Li Wenyang;Wang Wei;Department of Respiratory and Critical Care Medicine,The First Hospital of China Medical University;;Effect of hypothalamus-pituitary-target gland axis on cognitive impairment in patients with obstructive sleep apnea-hypopnea syndrome[J];国际内分泌代谢杂志;2018-05
2 Li Lanfeng;Yu Qin;Department of Respiratory Medicine,the First Clinical Medical College of Lanzhou University;;The research progress of obstructive sleep apnea-hypopnea syndrome and hypothalamic-pituitary-adrenal axis[J];国际呼吸杂志;2015-10
3 XIE Li-sheng,HUANG Qun(Department of Otorhinolaryngology,Nanjing Children′s Hospital Affiliated to Nanjing Medical University,Nanjing 210008,China);Changes of growth hormone secretion in children with obstructive sleep apnea syndrome[J];山东大学耳鼻喉眼学报;2011-04
4 LUO Qin*, QIN Chun-Chang, LIU Zhi-Hong, ZHAO Zhi-Hui ZHANG Hong-Liang, YANG Yue-Jin. *Center for Pulmonary Vascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, China. Corresponding author: LIU Zhi-Hong;Cardiovascular response to coronary angiography in patients with obstructive sleep apnea[J];中国分子心脏病学杂志;2011-01
5 XIANG Yong-hong,SU Xiao-li,HU Cheng-ping.Department of Respiratory Medicine, XiangYa Hospital,Central South University,Changsha 410008,China;Research progress in the mechanism of hypertension in patients with obstructive sleep apnea-hypopnea syndrome[J];国际呼吸杂志;2010-13
6 WEI Cui-ying~*, WANG Hui- ling, LI Jing, DONG Xiao-song, AN Pei, Jl Li-nong, WANG Fang, HAN Fang. ~*Department of RespiritoryMedicine, People's Hospital, Peking University, Bering 100044, China;Effect of continuous positive airway pressure upon 24 h changes of blood glucose level in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes[J];中华医学杂志;2009-38
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