Cardiovascular response to coronary angiography in patients with obstructive sleep apnea
LUO Qin*, QIN Chun-Chang, LIU Zhi-Hong, ZHAO Zhi-Hui ZHANG Hong-Liang, YANG Yue-Jin. *Center for Pulmonary Vascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, China. Corresponding author: LIU Zhi-Hong
Backgroud: Obstructive sleep apnea syndrome (OSA) is very common disease, which increases risks for the development of cardiovascular diseases. However, the underlying mechanisms are not understood. We aimed to observe whether patients with OSA had unfavorable cardiovascular responses to stress, which were risk factors for the development of hypertension.Methods: A retrospective study was carried out to observe OSA patients’ responses to stress through comparing their blood pressure and heart rate changes before, during and after coronary angiography in the sleep laboratory of center for pulmonary vascular diseases, Fuwai Hospital. Results: Fifty-six coronary artery disease patients with OSA and 18 coronary artery disease patients without OSA (No-OSA) were enrolled. In OSA patients, systolic blood pressure response to coronary angiography was exaggerated and diastolic blood pressure recovery was delayed compared with the No-OSA (P=0.047). No differences were noted in the heart rate response to coronary angiography between two groups. The increase in SBP during CAG was negatively correlated to 90% SaO2 (r=-0.222, p=0.031) and positively correlated to sleepiness score (r=0.257, p=0.028), but not related to AHI, ODI, and the lowest SaO2.Conclusions: Cardiovascular responses to coronary angiography in OSA patients were abnormal, reflected by an exaggerated systolic blood pressure response and delayed diastolic pressure recovery, which were associated with hypoxia and may play a role in cardiovascular complications of OSA patients.