Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Molecular Cardiology of China》 2011-01
Add to Favorite Get Latest Update

Effect of Hypertension on the In Vivo Reendothelialization Capacity of Endothelial Progenitor Cells

LIU Xing, ZHANG Gao-xing, XIA Wen-hao, YANG Zhen, TAO Jun. Department of Hypertension and Vascular Disease, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Department of Cardiology,JiangMen Central Hospital, JiangMen 529030, China.  
Objective To observe the effects of hypertension on the migration, adhesion and reendothelialization capacities of endothelial progenitor cells(EPCs).Methods Ten patients with hypertension and 10 age and sex-matched healthy subjects without other cardiovascular risk factors were enrolled into the study. The peripheral venous blood mononuclear cells from the subjects were inducted into EPCs, which were morphologically observed and identified by fluorescent immunological labeling. EPCs migration, adhesion and reendothelialization capacities were assayed after 7 days of culture. A nude mice carotid artery injury model was used to evaluate the reendothelialization capacity of EPCs derived from both patients and normal subjects. Results The peripheral blood mononuclear cells differentiated into EPCs. They were positively labeled by acetylated-LDL and 1ectin.In vitro migration, adhesion activities of EPCs were significantly impaired in patient with hypertension compared with healthy men. The in vivo reendothelialization capacity in EPCs from patient with hypertension was significantly reduced compared with normal subjects. Conclusion Hypertension impairs the migration, adhesion and reendothelialization function of EPCs, indicating that decreased endogenous repair capacity may be an important mechanism underlying vascular endothelial injury of hypertension.
【Fund】: 国家自然科学基金重点项目(u0732002)
【CateGory Index】: R544.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved