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Effects of Arachidonic Acid Cytochrome P450 Epoxygenase on Atherosclerosis Induced by Western Diet in Different Week-old Mice Model

WU Jun*, CHEN Chen, ZENG He-Song,WANG Dao-Wen.Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 ,China,* General Hospital of the Yangtze River Shipping,Wuhan,430010,China  
Objective To study whether overexpression of arachidonic acid cytochrome P450 (CYP) 2C8 epoxygenase genes improve Atherosclerosis in mice.Methods Overexpression CYP2C8 genes in endothelium of 20-week-old and 40-week-old of APOEKO+/- CYP2C8Tg+/-and CYP2C8Tg+/- mice were identified using PCR. The same aged APOEKO+/- and C57BL/6 mice were served as control (n=10). When the mice were sacrificed at 20 and 40 week of age, the index of atherosclerotic formation were measured by oil red O. Samples were used to measure nonfasting plasma total cholesterol, triglyceride and high density lipoprotein cholesterol concentration. Results Overexpression of CYP2C8 genes can ameliorate plasma total cholesterol, triglyceride and atherosclerotic formation in aortic. Conclusion There findings suggest that Overexpression CYP2C8 genes can improve Atherosclerosis induced by western diet in different week-old mice.
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