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《China Environmental Science》 2015-09
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Levels and risk assessment of bisphenol A and chlorinated BPAs in urine samples of Beijing women

CHEN Mo;FAN Zhan-lan;GAO Qun;GAO Fu-mei;MU Di;HU Jian-ying;College of Urban and Environmental Sciences, Peking University;  
A derivatization UPLC-MS-MS method was used to analyze bisphenol A(BPA) and its chlorinated derivatives, including monochloro-BPA, dichloro-BPA, tricholro-BPA, and tetrachloro-BPA, in 40 urine samples of Beijing women. The detection frequencies of BPA, monochloro-BPA, dichloro-BPA, tricholro-BPA, and tetrachloro-BPA were 90%, 96%, 90%, 52%, and 45% with average concentrations of(1.30±1.24),(0.40±0.37),(0.41±0.51),(0.18±1.49),(0.46±0.35) ng/m L, respectively. While the total concentration of four chlorinated BPA was 1.45ng/m L, which was similar with that of BPA in urine, their BPA toxic equivalent quantity(TEQBa P) in urine was calculated to be 4.84ng/m L, which was 2.2 fold higher than that of BPA. The TEQBPA concentration was log-normally distributed, and the probability higher than Benchmark Dose(BMDL0.05), corresponding to the increasing risk of diabetes by 0.05% due to exposure to BPA, was 19.2%. Our results indicated that chlorinated BPA might pose a relatively high risk.
【Fund】: 水体污染控制与治理科技重大专项(2014ZX07405001)
【CateGory Index】: X838;X820.4
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