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《China Poultry》 2018-24
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Applications of the Peptides in the Research of Influenza Virus

MA Chunxi;SONG Keke;HU Jiao;LIU Xiufan;Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University;Jiangsu Co-innovation Center for Prevention and Control of Important AnimalInfectious Diseases and Zoonosis;  
Peptides are widely found in nature. They are compounds in which α-amino acids are linked togetherby peptide chains. Since the development of synthetic peptide technology, polypeptides have been successfully used invarious fields, such as peptide vaccines, peptide inhibitors, peptide diagnostic reagents, peptide drugs. This article mainlyreviews the application of peptides in influenza virus research, including(1) peptide vaccines based on influenza virusHA and M2 e proteins;(2) screening of influenza virus HA, NA polypeptide inhibitors based on phage display librarytechnology and studying on the molecular mechanism of action of peptides against influenza virus;(3) peptide diagnosticreagents based on influenza virus M2 and HA proteins. In addition, the application of peptides in other virus researchare also briefly introduced. Finally, we conclude with a regarding of the future application prospects of peptides andthe problems that still need to be solved in future peptide applications.
【Fund】: 国家自然科学基金项目(31502076);; 江苏省自然科学基金项目(BK20150444);; 中国博士后基金特别资助计划(2016T90515);; 江苏高校优势学科建设工程资助项目(PAPD);; 扬州大学“高端人才支持计划”;; 江苏高校“青蓝工程”
【CateGory Index】: S852.65
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 YANG Fu-ru,YU Hai,MA Ji-hong,ZHOU Yan-jun,TONG Guang-zhi(Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China);DEVELOPMENT OF M2E BASED SYNTHETIC PEPTIDE AS UNIVERSAL INFLUENZA VACCINE[J];中国动物传染病学报;2013-01
2 KE Yan-kun,QI Yan,YE He-jia,ZHANG He-nan,CHEN Xiao-chun,LI Xiao-kang,YUAN Run-yu,QI Wen-bao,LIAO Ming(College of Veterinary Medicine,Human Agricultural University,Guangzhou 510642,China);Preliminary study of H5 subtype avian influenza virus polypeptide vaccine[J];中国兽医杂志;2008-12
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